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Recent advances in carbon-based nanomaterials for combating bacterial biofilm-associated infections

2022; Elsevier BV; Volume: 431; Linguagem: Inglês

10.1016/j.jhazmat.2022.128597

1873-3336

Fangchao Cui, Tingting Li, Dangfeng Wang, Shumin Yi, Jianrong Li, Xuepeng Li,

Carbon and Quantum Dots Applications

The prevalence of bacterial pathogens among humans has increased rapidly and poses a great threat to health. Two-thirds of bacterial infections are associated with biofilms. Recently, nanomaterials have emerged as anti-biofilm agents due to their enormous potential for combating biofilm-associated infections and infectious disease management. Among these, relatively high biocompatibility and unique physicochemical properties of carbon-based nanomaterials (CBNs) have attracted wide attention. This review presented the current advances in anti-biofilm CBNs. Different kinds of CBNs and their physicochemical characteristics were introduced first. Then, the various potential mechanisms underlying the action of anti-biofilm CBNs during different stages were discussed, including anti-biofouling activity, inhibition of quorum sensing, photothermal/photocatalytic inactivation, oxidative stress, and electrostatic and hydrophobic interactions. In particular, the review focused on the pivotal role played by CBNs as anti-biofilm agents and delivery vehicles. Finally, it described the challenges and outlook for the development of more efficient and bio-safer anti-biofilm CBNs.