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Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers

2022; Centers for Disease Control and Prevention; Volume: 28; Issue: 4 Linguagem: Inglês

10.3201/eid2804.212037

1080-6059

Eric D. Laing, Carol D. Weiss, E Samuels, Si’Ana A. Coggins, Wei Wang, Richard Wang, Russell Vassell, Spencer L. Sterling, Marana S Tso, Tonia L. Conner, Emilie Goguet, Matthew Moser, Belinda M. Jackson-Thompson, Luca Illinik, Julian Davies, Orlando Ortega, Edward Parmelee, Monique Hollis-Perry, Santina Maiolatesi, Gregory Wang, Kathleen F. Ramsey, Anatalio Reyes, Yolanda Alcorta, Mimi Wong, Alyssa R. Lindrose, Christopher Duplessis, David R. Tribble, Allison M.W. Malloy, Timothy Burgess, Simon Pollett, Cara Olsen, Christopher C. Broder, Edward Mitre,

COVID-19 epidemiological studies

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.