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BIBTEX RIS

Effects of polysaccharides isolated from mushrooms (Lentinus edodes Berk or Agaricus blazei Murill) on the gelation of Pluronic® F127

2022; Elsevier BV; Volume: 642; Linguagem: Inglês

10.1016/j.colsurfa.2022.128684

1873-4359

Thiago M.F. Menezes, Matheus da Silva Campelo, Ana Beatriz Nogueira Lima, João Francisco Câmara Neto, Matheus Morais Saraiva, João Antônio Costa de Sousa, Maria Leônia da Costa Gonzaga, Luzia Kalyne Almeida Moreira Leal, Maria Elenir Nobre Pinho Ribeiro, Nágila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares,

Pharmacological Effects of Natural Compounds

This study evaluated the effects of polysaccharides isolated from Lentinus edodes Berk and Agaricus blazei Murill mushrooms on the gelation process of the Pluronic® F127 (F127) copolymer. The structural characterization of these biopolymers suggested the isolation of an β-glucan L. edodes Berk (LEB) and a proteoglycan complex A. blazei Murill (ABM). Both polysaccharides showed good rheological properties for developing pharmaceutical formulations with antioxidant activity and low cytotoxicity in human neutrophils. The characterization of the gels formed from the mixture of polysaccharides with aqueous solutions of F127 showed that the presence of these biopolymers reduces the temperature range in which F127 remains in the gel phase (G’ > G’’). Furthermore, the thermoresponsive behavior of F127 was not lost, which favors the development of hydrogels with potential for topical use.