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SARS‐COV‐2 genomic monitoring in the state of São Paulo unveils two emerging AY.43 sublineages

2022; Wiley; Volume: 94; Issue: 7 Linguagem: Inglês

10.1002/jmv.27674

1096-9071

Alex Ranieri Jerônimo Lima, Gabriela Ribeiro, Vincent Louis Viala, Loyze Paola Oliveira de Lima, Antonio Jorge Martins, Cláudia Renata dos Santos Barros, Elaine Cristina Marqueze, Jardelina de Souza Todão Bernardino, Débora Botéquio Moretti, Evandra Strazza Rodrigues, Elaine Vieira Santos, Ricardo Augusto Brassaloti, Raquel de Lello Rocha Campos Cassano, Pilar Mariani, Luan Gaspar Clemente, Patrícia Akemi Assato, Felipe Allan da Silva da Costa, Mirele Poleti, Jéssika Cristina Chagas Lesbon, E. C. Mattos, Cecília Ártico Banho, Lívia Sacchetto, Marília Mazzi Moraes, Melissa Palmieri, Maiara Martininghi, Luiz Artur Vieira Caldeira, Fabiana Érica Vilanova da Silva, Rejane Maria Tommasini Grotto, Jayme A. Souza‐Neto, Marta Giovanetti, Luíz Carlos Júnior Alcântara, Maurício Lacerda Nogueira, Heidge Fukumasu, Luiz Lehmann Coutinho, Simone Kashima, Raul Machado Neto, Dimas Tadeu Covas, Svetoslav Nanev Slavov, Sandra Coccuzzo Sampaio, Maria Carolina Elias,

Viral gastroenteritis research and epidemiology

Abstract Delta VOC is highly diverse with more than 120 sublineages already described as of November 30, 2021. In this study, through active monitoring of circulating severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) variants in the state of São Paulo, southeast Brazil, we identified two emerging sublineages from the ancestral AY.43 strain which were classified as AY.43.1 and AY.43.2. These sublineages were defined by the following characteristic nonsynonymous mutations ORF1ab:A4133V and ORF3a:T14I for the AY.43.1 and ORF1ab:G1155C for the AY.43.2 and our analysis reveals that they might have a likely‐Brazilian origin. Much is still unknown regarding their dissemination in the state of São Paulo and Brazil as well as their potential impact on the ongoing vaccination process. However, the results obtained in this study reinforce the importance of genomic surveillance activity for timely identification of emerging SARS‐CoV‐2 variants which can impact the ongoing SARS‐CoV‐2 vaccination and public health policies.