Suzuki–Miyaura Cross‐Coupling Reactions in Flow: Multistep Synthesis Enabled by a Microfluidic Extraction
2011; Wiley; Volume: 123; Issue: 26 Linguagem: Alemão
10.1002/ange.201101480
ISSN1521-3757
AutoresTimothy Noël, Simon Kuhn, Andrew J. Musacchio, Klavs F. Jensen, Stephen L. Buchwald,
Tópico(s)Chemical synthesis and alkaloids
ResumoAngewandte ChemieVolume 123, Issue 26 p. 6065-6068 Zuschrift Suzuki–Miyaura Cross-Coupling Reactions in Flow: Multistep Synthesis Enabled by a Microfluidic Extraction† Dr. Timothy Noël, Dr. Timothy Noël Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/Search for more papers by this authorDr. Simon Kuhn, Dr. Simon Kuhn Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)Search for more papers by this authorAndrew J. Musacchio, Andrew J. Musacchio Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/Search for more papers by this authorProf. Dr. Klavs F. Jensen, Corresponding Author Prof. Dr. Klavs F. Jensen kfjensen@mit.edu Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA) Klavs F. Jensen, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA) Stephen L. Buchwald, Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/Search for more papers by this authorProf. Dr. Stephen L. Buchwald, Corresponding Author Prof. Dr. Stephen L. Buchwald sbuchwal@mit.edu Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/ Klavs F. Jensen, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA) Stephen L. Buchwald, Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/Search for more papers by this author Dr. Timothy Noël, Dr. Timothy Noël Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/Search for more papers by this authorDr. Simon Kuhn, Dr. Simon Kuhn Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)Search for more papers by this authorAndrew J. Musacchio, Andrew J. Musacchio Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/Search for more papers by this authorProf. Dr. Klavs F. Jensen, Corresponding Author Prof. Dr. Klavs F. Jensen kfjensen@mit.edu Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA) Klavs F. Jensen, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA) Stephen L. Buchwald, Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/Search for more papers by this authorProf. Dr. Stephen L. Buchwald, Corresponding Author Prof. Dr. Stephen L. Buchwald sbuchwal@mit.edu Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/ Klavs F. Jensen, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA) Stephen L. Buchwald, Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297 http://mit.edu/chemistry/buchwald/Search for more papers by this author First published: 17 May 2011 https://doi.org/10.1002/ange.201101480Citations: 52 † T.N., S.K., A.J.M., K.F.J., and S.L.B. thank the Novartis International AG for funding. T.N. is a Fulbright Postdoctoral Fellow. S.K. acknowledges funding from the Swiss National Science Foundation (SNF). A.J.M. is an Undergraduate Research Opportunities Program (U.R.O.P.) student at Massachusetts Institute of Technology. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Steter Erfolg: Eine Suzuki-Miyaura-Kreuzkupplung, die von Phenolen ausgeht, wurde in einem kontinuierlichen Strömungssystem durch die Anwendung einer effizienten mikrofluidischen Extraktion in Kombination mit einem Festbettreaktor ermöglicht. 14 verschiedene Biaryle wurden in ausgezeichneten Ausbeuten erhalten. TBAB=Bu4N+Br−. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description ange_201101480_sm_miscellaneous_information.pdf2.7 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume123, Issue26June 20, 2011Pages 6065-6068 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation
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