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Subconjunctival gentamicin.

1971; BMJ; Volume: 55; Issue: 7 Linguagem: Inglês

10.1136/bjo.55.7.478

1468-2079

D B Goulstine, V. J. Marmion,

Intraocular Surgery and Lenses

Gentamicin sulphate is a new broad spectrum antibiotic produced by Micromonospora purpurea, and is active against both Gram-positive and Gram-negative bacteria.The antibiotics which have hitherto been used subconjunctivally all have some dis- advantages.Penicillin, which is only mildly irritant, has a range of activity which does not cover the Gram-negative bacilli, Pseudomonas, Proteus, or E. coli.In addition, most strains of staphylococci may become resistant.Streptomycin is useful but resistant strains develop quickly.Polymyxin and Neomycin are rarely used because the injections are painful and irritant to the tissues.Soframycin is a useful antibiotic, being active against both Gram-positive cocci and Gram-negative bacilli, but repeated injections are slightly irritant to the tissues and systemic absorption may have nephrotoxic and ototoxic effects.