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The Margins’ Challenge: Risk Factors of Residual Disease After Breast Conserving Surgery in Early-stage Breast Cancer

2022; Stanford University Highwire Press; Volume: 36; Issue: 2 Linguagem: Inglês

10.21873/invivo.12768

1791-7549

Piero Fregatti, Marco Gipponi, Giulia Atzori, Raffaele De Rosa, Raquel Díaz, Chiara Cornacchia, Marco Sparavigna, Alessandro Garlaschi, Liliana Belgioia, Alessandra Fozza, Francesca Pitto, Luca Boni, Eva Blondeaux, Francesca Depaoli, Federica Murelli, Simonetta Franchelli, Gabriele Zoppoli, Matteo Lambertini, Daniele Friedman,

Breast Implant and Reconstruction

Clinicopathological features of patients undergoing margin enlargement after lumpectomy for early breast cancer with positive/close excision margins were analyzed in order to define whether a re-operative procedure could have been avoided. Furthermore, a standardized protocol of specimen orientation was adopted in order to optimize both the widening procedure as well as the oncologic outcome.A retrospective analysis was performed including pre-, peri-, and post-operative parameters, and a predictive score by means of a multivariate model was developed using all clinically and statistically significant variables associated with residual disease (RD).RD was significantly related to positive tumor margins, hormone receptor negative, HER2-positive, and tumors with high Ki67 proliferation index (p 3, only 2 patients (2.0%) had RD, while in 81 patients with a score ≤3, 55 patients (67.9%) had RD (p<0.001).This predictive model might aid in clinical-decision making of patients with positive margins who actually require a widening procedure after intraoperative and/or definitive histology.