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Virtual Ontogeny of Cortical Growth Preceding Mental Illness

2022; Elsevier BV; Volume: 92; Issue: 4 Linguagem: Inglês

10.1016/j.biopsych.2022.02.959

1873-2402

Yash Patel, Jean Shin, Christoph Abé, Ingrid Agartz, Clara Alloza, Dag Alnæs, Sonia Ambrogi, Linda A. Antonucci, Celso Arango, Volker Arolt, Guillaume Auzias, Rosa Ayesa‐Arriola, Nerisa Banaj, Tobias Banaschewski, Cibele Edom Bandeira, Zeynep Başgöze, Renata B. Cupertino, Claiton H.D. Bau, Jochen Bauer, Sarah Baumeister, Fabio Bernardoni, Alessandro Bertolino, Caterina del Mar Bonnín, Daniel Brandeis, Silvia Brem, Jason Bruggemann, Robin Bülow, Juan Bustillo, Sara Calderoni, Rosa Calvo, Erick J. Canales‐Rodríguez, Dara M. Cannon, Susanna Carmona, Vaughan J. Carr, Stanley V. Catts, Sneha Chenji, Qian Hui Chew, David Coghill, Colm G. Connolly, Annette Conzelmann, Alexander R. Craven, Benedicto Crespo‐Facorro, Kathryn R. Cullen, Andreas Dahl, Udo Dannlowski, Christopher G. Davey, Christine Deruelle, Covadonga M. Díaz‐Caneja, Katharina Dohm, Stefan Ehrlich, Jeffery N. Epstein, Tracy Erwin-Grabner, Lisa T. Eyler, Jennifer Fedor, Jacqueline Fitzgerald, Will Foran, Judith M. Ford, Lydia Fortea, Paola Fuentes‐Claramonte, Janice M. Fullerton, Lisa S. Furlong, Louise Gallagher, Bingchen Gao, Si Gao, José Manuel Goikolea, Ian H. Gotlib, Roberto Goya‐Maldonado, Hans J. Grabe, Melissa J. Green, Eugênio H. Grevet, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Jan Haavik, Tim Hahn, Ben J. Harrison, Walter Heindel, Frans Henskens, Dirk J. Heslenfeld, Eva Hilland, Pieter J. Hoekstra, Sarah Hohmann, Nathalie Holz, Fleur M. Howells, Jonathan Ipser, Neda Jahanshad, Babette Jakobi, Andreas Jansen, Joost Janssen, Rune Jonassen, Anna Kaiser, Vasiliy G. Kaleda, James A. Karantonis, Joseph A. King, Tilo Kircher, Peter Kochunov, Sheri‐Michelle Koopowitz, Mikael Landén, Nils Inge Landrø, Stephen M. Lawrie, Irina Lebedeva, Beatriz Luna, Astri J. Lundervold, Frank P. MacMaster, Luigi A. Maglanoc, Daniel H. Mathalon, Colm McDonald, Andrew M. McIntosh, Susanne Meinert, Patricia T. Michie, Philip B. Mitchell, Ana Moreno‐Alcázar, Bryan Mowry, Filippo Muratori, Leila Nabulsi, Igor Nenadić, Ruth Tuura, Jaap Oosterlaan, Bronwyn J. Overs, Christos Pantelis, Mara Parellada, José C. Pariente, Paul Pauli, Giulio Pergola, Francesco Maria Piarulli, Felipe Almeida Picon, Fabrizio Piras, Edith Pomarol‐Clotet, Clara Pretus, Yann Quidé, Joaquim Raduà, Josep Antoni Ramos‐Quiroga, Paul E. Rasser, Andreas Reif, Alessandra Retico, Gloria Roberts, Susan L. Rossell, Diego Luiz Rovaris, Katya Rubia, Matthew D. Sacchet, Josep Salavert, Raymond Salvador, Salvador Sarró, Akira Sawa, Ulrich Schall, Rodney J. Scott, Pierluigi Selvaggi, Timothy J. Silk, Kang Sim, Antonín Škoch, Gianfranco Spalletta, Filip Španiel, Dan J. Stein, Olaf Steinsträter, Aleks Stolicyn, Yoichiro Takayanagi, Leanne Tamm, Maria Eduarda Tavares, Alexander Teumer, Katharina Thiel, Sophia I. Thomopoulos, David Tomeček, Alexander S. Tomyshev, Diana Tordesillas‐Gutiérrez, Michela Tosetti, Anne Uhlmann, Tamsyn E. Van Rheenen, Javier Vázquez‐Bourgon, Meike W. Vernooij, Eduard Vieta, Óscar Vilarroya, Cynthia Shannon Weickert, Thomas W. Weickert, Lars T. Westlye, Heather C. Whalley, David Willinger, Alexandra Winter, Katharina Wittfeld, Tony T. Yang, Yuliya Yoncheva, Jendé L. Zijlmans, Martine Hoogman, Barbara Franke, Daan van Rooij, Jan K. Buitelaar, Christopher R. K. Ching, Ole A. Andreassen, Elena Pozzi, Dick J. Veltman, Lianne Schmaal, Theo G.M. van Erp, Jessica Turner, F. Xavier Castellanos, Zdenka Pausová, Paul M. Thompson, Tomáš Paus,

Tryptophan and brain disorders

Background Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life. Methods Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed. Results Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth. Conclusions Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.