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The Predictive Ability of the C-reactive Protein to Albumin Ratio As A Mortality Predictor in Hospitalized Severe SARS-CoV-2 Infected Patients with Cardiovascular Diseases

2022; Galenos Yayinevi; Volume: 60; Issue: 2 Linguagem: Inglês

10.4274/haseki.galenos.2022.7745

2147-2688

Fahrettin Katkat, Muhsin Kalyoncuoğlu, Serkan Karahan, Sevgi Özcan, Zeynep Atam Taşdemir, Suat Hayri Küçük, Umut Karabulut, Ahmet Güner, Halil İbrahim Biter, Fatma Nihan Turhan Çağlar, Ertuğrul Okuyan,

Pancreatitis Pathology and Treatment

Aim:Although there are few studies on the predictive value of C-reactive protein-to-albumin ratio (CAR) in coronavirus disease-2019 (COVID-19) patients, to the best of our knowledge, there are no studies specifically conducted in COVID-19 patients with cardiovascular disease (CVD).This study assessed the use of baseline CAR levels to predict death in hospitalized COVID-19 patients with CVD.Methods: This study was designed as a single-center cross-sectional study.Patients diagnosed with COVID-19 who were admitted to the University of Health Sciences Turkey, Bagcilar Training and Research Hospital between April 16 and May 20, 2020 were analyzed retrospectively.The patients were divided into 2 groups: those who died and those who survived, considering the follow-up period.The CAR values of the study population, as well as patients with CVD, were calculated, and the association of CAR with in-hospital mortality was evaluated. Results:The in-hospital mortality rate was 11.1% (49/442 pts) in all populations.Deceased patients had significantly more frequent CVD (p <0.001) and the mortality rate was 34.4% (30/96 pts) in those patients.Median CAR values were higher in nonsurvivors than among survivors (p<0.001).Multivariate analysis demonstrated that CAR was an independent predictor of mortality in patients with CVD [hazard ratio 1.013 (95% confidence interval: 1.002-1.022),p=0.018]. Conclusion:CAR is an inflammatory risk marker that independently predicts mortality in all COVID-19 hospitalized patients and patients with CVD.