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Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

2022; BMJ; Volume: 77; Issue: 7 Linguagem: Inglês

10.1136/thoraxjnl-2021-218582

1468-3296

Linzy Houchen‐Wolloff, Krisnah Poinasamy, Kate Holmes, Maryrose Tarpey, Claire Hastie, Kelly Raihani, Natalie Rogers, Nikki Smith, Dawn Adams, Paul Burgess, Jean C. Clark, Clare Cranage, Mahadev H. Desai, Nicola Geary, Rhyan Gill, Jitendra Mangwani, Lily Staunton, Colin Berry, Charlotte E. Bolton, Trudie Chalder, James D. Chalmers, Anthony De Soyza, Omer Elneima, John Geddes, Simon Heller, Ling‐Pei Ho, Joseph Jacob, Hamish McAuley, Aarti Parmar, Jennifer K Quint, Betty Raman, Matthew Rowland, Amisha Singapuri, Sally Singh, David Thomas, Mark Toshner, Louise V. Wain, Alex Horsley, Michael Marks, Christopher E Brightling, Rachael A. Evans,

Neuroinflammation and Neurodegeneration Mechanisms

Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts, we completed a research prioritisation process incorporating views from adults with ongoing symptoms of COVID-19, carers, clinicians and clinical researchers. The final top 10 research questions were agreed at an independently mediated workshop and included: identifying underlying mechanisms of long COVID, establishing diagnostic tools, understanding trajectory of recovery and evaluating the role of interventions both during the acute and persistent phases of the illness.