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Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

2022; Elsevier BV; Volume: 101; Issue: 6 Linguagem: Inglês

10.1016/j.kint.2022.03.011

1523-1755

Rajasree Menon, Andrew S. Bomback, Blue B. Lake, Christy Stutzke, Stephanie M. Grewenow, Steven Menez, Vivette D. D’Agati, Sanjay Jain, Richard Knight, Stewart H. Lecker, Isaac E. Stillman, Steve Bogen, Laurence H. Beck, Sushrut S. Waikar, Gearoid M. McMahon, Astrid Weins, Mia R. Colona, Nir Hacohen, Paul Hoover, Mark P. Aulisio, William S. Bush, Dana C. Crawford, John O’Toole, Emilio D. Poggio, John R. Sedor, Leslie Cooperman, Stacey E. Jolly, Leal Herlitz, Jane Nguyen, Agustin Gonzalez‐Vicente, Ellen L. Palmer, Dianna Sendrey, Carissa Vinovskis, P. M. Bjørnstad, Paul S. Appelbaum, Jonathan Barasch, Andrew S. Bomback, Vivette D. D’Agati, Krzysztof Kiryluk, Karla Mehl, Pietro A. Canetta, Ning Shang, Olivia Balderes, Satoru Kudose, Shweta Bansal, Theodore Alexandrov, Helmut G. Rennke, Tarek M. El‐Achkar, Ying‐Hua Cheng, Pierre C. Dagher, Michael T. Eadon, Kenneth W. Dunn, Katherine J. Kelly, Timothy A. Sutton, Daria Barwinska, Michael J. Ferkowicz, Seth Winfree, Sharon B. Bledsoe, Marcelino Rivera, James C. Williams, Ricardo Melo Ferreira, Chirag R. Parikh, Celia P. Corona-Villalobos, Steven Menez, Avi Z. Rosenberg, Sylvia E. Rosas, Neil Roy, Mark V. Williams, Evren U. Azeloglu, Cijang He, Ravi Iyengar, Jens Hansen, Yuguang Xiong, Brad H. Rovin, Samir V. Parikh, John P. Shapiro, Christopher Anderton, Ljiljana Paša‐Tolić, Dušan Veličković, Jessica Lukowski, George Oliver, Joseph Ardayfio, Jack Bebiak, Keith Brown, Catherine E. Campbell, John Saul, Anna Shpigel, Christy Stutzke, Robert Koewler, Taneisha Campbell, Lynda Hayashi, Nichole Jefferson, Glenda V. Roberts, Roy Pinkeney, Olga G. Troyanskaya, Rachel Sealfon, Katherine R. Tuttle, Yury Goltsev, Kun Zhang, Blue B. Lake, Zoltán Lászik, Garry P. Nolan, Patrick Boada, Minnie Sarwal, Tara K. Sigdel, Paul J. Lee, Rita R. Alloway, E. Steve Woodle, Heather Ascani, Ulysses J. Balis, Jeffrey B. Hodgin, Matthias Kretzler, Chrysta Lienczewski, Laura Mariani, Rajasree Menon, Becky Steck, Yougqun He, Edgar A. Otto, Jennifer A. Schaub, Victoria M. Blanc, Sean Eddy, Ninive C. Conser, Jinghui Luo, Paul M. Palevsky, Matthew R. Rosengart, John A. Kellum, Daniel E. Hall, Parmjeet Randhawa, Mitchell Tublin, Raghavan Murugan, Michele Elder, James Winters, Charles E. Alpers, Kristina N. Blank, Jonas Carson, Ian H. de Boer, Ashveena Dighe, Jonathan Himmelfarb, Sean D. Mooney, Stuart J. Shankland, Kayleen Williams, Chris Park, Frederick Dowd, Robyn L. McClelland, Stephen Daniel, Andrew N. Hoofnagle, Adam B. Wilcox, Stephanie M. Grewenow, Shweta Bansal, Kumar Sharma, Manjeri A. Venkatachalam, Guanshi Zhang, Annapurna Pamreddy, Hongping Ye, Richard Montellano, Robert D. Toto, Miguel A. Vazquez, Simon J. Craddock Lee, R. Tyler Miller, Orson W. Moe, José Torrealba, Nancy Wang, Asra Kermani, Kamalanathan K. Sambandam, Harold S. Park, S. Susan Hedayati, Christopher Y. Lu, Sanjay Jain, Anitha Vijayan, Joseph P. Gaut, Dennis G. Moledina, F. Perry Wilson, Ugochukwu Ugwuowo, Tanima Arora,

Renal and related cancers

Acute kidney injury (AKI) induces a broad range of clinically significant perturbations in kidney morphology and function. Insights into the molecular and cellular basis governing a clinical-pathologic course are limited by the availability of molecular maps of healthy and injured kidney cells. The Kidney Precision Medicine Project (KPMP) and the Human Biomolecular Atlas Project (HuBMAP) have generated a comprehensive molecular atlas of the kidney from more than 400,000 cells that define healthy and injured cell types and states in AKI and chronic kidney disease. 1 de Boer I.H. Alpers C.E. Azeloglu E.U. et al. Rationale and design of the Kidney Precision Medicine Project. Kidney Int. 2021; 99: 498-510 Abstract Full Text Full Text PDF PubMed Scopus (63) Google Scholar ,2 Tuttle K.R. Bebiak J. Brown K. et al. Patient perspectives and involvement in precision medicine research. Kidney Int. 2021; 99: 511-514 Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar Using the atlas as a resource to perform deep interrogation of a biopsy from a patient participant with AKI, we applied single-cell analysis and detailed morphologic and pathway analysis to gain molecular insights into cellular diversity, injury states, and outcome. In this issueKidney InternationalVol. 101Issue 6PreviewIn this issue of Kidney International, we are pleased to introduce a new article series called Next Generation Clinical Pathologic Conference (CPC). These articles will merge the traditional CPC with molecular medicine for a fresh approach to decipher mechanisms of kidney disease. In cooperation with the National Institutes of Health–sponsored Kidney Precision Medicine Project, biopsies from patients with chronic kidney disease (CKD) or acute kidney injury (AKI) that have been interrogated with cutting-edge molecular technologies will be reviewed and correlated with clinical and histopathologic findings. Full-Text PDF