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Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients

2022; Multidisciplinary Digital Publishing Institute; Volume: 23; Issue: 7 Linguagem: Inglês

10.3390/ijms23073860

1661-6596

Roberta Papagni, Carmen Pellegrino, Francesco Di Gennaro, Giulia Patti, Aurelia Ricciardi, Roberta Novara, Sergio Cotugno, Maria Musso, Giacomo Guido, Luigi Ronga, Stefania Stolfa, Davide Fiore Bavaro, Federica Romanelli, Valentina Totaro, Rossana Lattanzio, Giuseppina De Iaco, Fabrizio Palmieri, Annalisa Saracino, Gina Gualano,

Tuberculosis Research and Epidemiology

Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world's top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the replication of Mycobacterium tuberculosis in vitro and showed a promising role in TB management as a result of its connection with oxidative balance. Our review encourages the possible in vivo benefit of a joint administration with other vitamins, such as vitamin A, which share a known antimycobacterial action with vitamin D. However, considering the low incidence of side effects even at high dosages and its low cost, it would be advisable to assess vitamin D level both in patients with active TB and high-risk groups and administer it, at least to reach sufficiency levels.