Portal de Periódicos da CAPES

Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma

2022; Bentham Science Publishers; Volume: 22; Issue: 9 Linguagem: Inglês

10.2174/1568009622666220317090552

1873-5576

Lekshmi R. Nath, Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, R Nair,

Monoclonal and Polyclonal Antibodies Research

Mucin 1 (MUC 1) is a highly glycosylated tumor-associated antigen (TAA) overexpressed in hepatocellular carcinoma (HCC). This protein plays a critical role in various immune-mediated signaling pathways at its transcriptional and post-transcriptional levels, leading to immune evasion and metastasis in HCC. HCC cells maintain an immune-suppressive environment with the help of immunesuppressive tumor-associated antigens, resulting in a metastatic spread of the disease. The development of intense immunotherapeutic strategies to target tumor-associated antigen is critical to overcoming the progression of HCC. MUC 1 remains the most recognized tumor-associated antigen since its discovery over 30 years ago. A few promising immunotherapies targeting MUC 1 are currently under clinical trials, including CAR-T and CAR-pNK-mediated therapies. This review highlights the biosynthesis, significance, and clinical implication of MUC 1 as an immune target in HCC.