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E-Volve: understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces

2022; PeerJ, Inc.; Volume: 10; Linguagem: Inglês

10.7717/peerj.13099

2167-8359

Vitor Pimentel Dos Santos, André Rodrigues, Gabriel Dutra, Luana Luiza Bastos, Diego Mariano, José Gutembergue de Mendonça, Yan Jerônimo Gomes Lobo, Eduardo Mazoni Andrade Marçal Mendes, Giovana Maia, Karina Machado, Adriano Velasque Werhli, Gerd B. Rocha, Leonardo Henrique França de Lima, Raquel C. de Melo-Minardi,

Viral Infections and Immunology Research

The SARS-CoV-2 pandemic reverberated, posing health and social hygiene obstacles throughout the globe. Mutant lineages of the virus have concerned scientists because of convergent amino acid alterations, mainly on the viral spike protein. Studies have shown that mutants have diminished activity of neutralizing antibodies and enhanced affinity with its human cell receptor, the ACE2 protein.