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Anti‐Inflammatory Markers of Hops Cultivars ( Humulus lupulus L.) Evaluated by Untargeted Metabolomics Strategy

2022; Wiley; Volume: 19; Issue: 4 Linguagem: Inglês

10.1002/cbdv.202100966

1612-1880

Karen de Jesus Nicácio, Miller Santos Ferreira, Albert Katchborian‐Neto, Milbya Lima Costa, Michael Murgu, Danielle Ferreira Dias, Marisi G. Soares, Daniela Aparecida Chagas‐Paula,

Ginseng Biological Effects and Applications

Hops (Humulus lupulus L.) are edible flowers commonly used to add flavour and aroma to beer, besides they have rich chemical diversity and medicinal potential. In this work, an ex vivo anti-inflammatory assay via the LPS-induced signalling pathway and metabolomics approaches were performed to evaluate the ability of hops to inhibit the production of prostaglandin E2 (PGE2) inflammatory mediator and analyze which metabolites produced by the nine different hop cultivars are potential anti-inflammatory markers. Columbus, Chinook and Hallertau Mittelfrüh hop cultivars yielded extracts with PGE2 release inhibition rates of 86.7, 92.5 and 73.5 %, respectively. According to the multivariate statistical analysis, the majority of the metabolites correlated with the activity were prenylated phloroglucinol and phenolic homologs. These results suggest promissory anti-inflammatory hop metabolites.