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Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

2022; American Society for Microbiology; Volume: 96; Issue: 8 Linguagem: Inglês

10.1128/jvi.00128-22

1098-5514

Rachid Essalmani, Jaspreet Jain, Delia Susan‐Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto‐Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Étienne Decroly, Tram N. Q. Pham, Éric A. Cohen, Nabil G. Seidah,

Phagocytosis and Immune Regulation

SARS-CoV-2, the etiological agent of COVID-19, has so far resulted in >6.1 million deaths worldwide. The spike protein (S) of the virus directs infection of the lungs and other tissues by binding the angiotensin-converting enzyme 2 (ACE2) receptor.