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Immune-mediated thrombotic thrombocytopenic purpura following COVID-19 vaccination

2022; Elsevier BV; Volume: 139; Issue: 16 Linguagem: Inglês

10.1182/blood.2021015149

1528-0020

Adrien Picod, Jean-Michel Rebibou, Antoine Dossier, Bérengère Cador, David Ribes, Claire Vasco‐Moynet, Caroline Stephan, Mathieu Bellal, Alain Wynckel, Pascale Poullin, Edwige Péju, Laure Ricard, Jean‐Emmanuel Kahn, Raïda Bouzid, Y. Benhamou, Bérangère S. Joly, Agnès Veyradier, Paul Coppo,

Platelet Disorders and Treatments

Letter to Blood| April 21, 2022 Immune-mediated thrombotic thrombocytopenic purpura following COVID-19 vaccination Clinical Trials & Observations Adrien Picod, Adrien Picod 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;2Service de réanimation médico-chirurgicale, Hôpital Avicenne Assistance Publique–Hôpitaux de Paris (AP-HP), Bobigny, France; https://orcid.org/0000-0002-0639-5598 Search for other works by this author on: This Site PubMed Google Scholar Jean-Michel Rebibou, Jean-Michel Rebibou 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;3Service de Néphrologie, Centre Hospitalier Universitaire (CHU) Dijon Bourgogne, Dijon, France; Search for other works by this author on: This Site PubMed Google Scholar Antoine Dossier, Antoine Dossier 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;4Service de médecine interne, Hôpital Bichat-Claude Bernard, Assistance Publique–Hôpitaux de Paris, France; https://orcid.org/0000-0002-2008-2942 Search for other works by this author on: This Site PubMed Google Scholar Bérengère Cador, Bérengère Cador 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;5Service de médecine interne et immunologie clinique, CHU de Rennes, Rennes, France; Search for other works by this author on: This Site PubMed Google Scholar David Ribes, David Ribes 6Département de néphrologie et transplantation d’organes, centre de référence des maladies rénales rares, centre hospitalier Universitaire de Toulouse, Toulouse, France; Search for other works by this author on: This Site PubMed Google Scholar Claire Vasco-Moynet, Claire Vasco-Moynet 7Service de médecine interne, centre hospitalier de Libourne, Libourne, France; Search for other works by this author on: This Site PubMed Google Scholar Caroline Stephan, Caroline Stephan 8Département de médecine, unité de médecine transfusionnelle et d’immunohématologie, hôpitaux universitaires de Genève, Suisse; Search for other works by this author on: This Site PubMed Google Scholar Mathieu Bellal, Mathieu Bellal 9Service de médecine intensive et réanimation, CHU de Caen, Caen, France; Search for other works by this author on: This Site PubMed Google Scholar Alain Wynckel, Alain Wynckel 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;10Service de néphrologie, CHU de Reims, Reim, France; Search for other works by this author on: This Site PubMed Google Scholar Pascale Poullin, Pascale Poullin 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;11Service d’hémaphérèse autotransfusion, centre de compétences pour les microangiopathies thrombotiques, hôpital la conception, Marseille, France; Search for other works by this author on: This Site PubMed Google Scholar Edwige Péju, Edwige Péju 12Service de médecine intensive et réanimation, hôpital Cochin, Assistance Publique–Hôpitaux de Paris, France; https://orcid.org/0000-0001-7356-7858 Search for other works by this author on: This Site PubMed Google Scholar Laure Ricard, Laure Ricard 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;13Service d’hématologie, Hôpital Saint-Antoine, Assistance Publique–Hôpitaux de Paris, Sorbonne-Université (AP-HP.6), Paris, France; https://orcid.org/0000-0003-4416-3285 Search for other works by this author on: This Site PubMed Google Scholar Jean-Emmanuel Kahn, Jean-Emmanuel Kahn 14Service de médecine interne, Hôpital Ambroise Paré, Assistance Publique–Hôpitaux de Paris, Université Versailles-Saint Quentin-en-Yvelines, Boulogne-Billancourt, France; Search for other works by this author on: This Site PubMed Google Scholar Raïda Bouzid, Raïda Bouzid 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France; https://orcid.org/0000-0003-1419-3758 Search for other works by this author on: This Site PubMed Google Scholar Ygal Benhamou, Ygal Benhamou 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;15Département de médecine interne, Hôpital universitaire de Rouen, Université de Normandie, Rouen, France; Search for other works by this author on: This Site PubMed Google Scholar Bérangère Joly, Bérangère Joly 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;16Service d’hématologie biologique, laboratoire ADAMTS13, Hôpital Lariboisière, AP-HP.Nord, Université de Paris, Paris, France;17EA3518, Institut de recherche Saint Louis, Université de Paris, Paris, France; and Search for other works by this author on: This Site PubMed Google Scholar Agnès Veyradier, Agnès Veyradier 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;16Service d’hématologie biologique, laboratoire ADAMTS13, Hôpital Lariboisière, AP-HP.Nord, Université de Paris, Paris, France;17EA3518, Institut de recherche Saint Louis, Université de Paris, Paris, France; and Search for other works by this author on: This Site PubMed Google Scholar Paul Coppo Paul Coppo 1Centre National de Référence des MicroAngiopathies Thrombotiques, Paris, France;13Service d’hématologie, Hôpital Saint-Antoine, Assistance Publique–Hôpitaux de Paris, Sorbonne-Université (AP-HP.6), Paris, France;18INSERM UMRS 1138, Centre de Recherche des Cordeliers, Paris, France Search for other works by this author on: This Site PubMed Google Scholar Blood (2022) 139 (16): 2565–2569. https://doi.org/10.1182/blood.2021015149 Article history Submitted: December 13, 2021 Accepted: February 8, 2022 First Edition: March 10, 2022 Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Request Permissions Cite Icon Cite Search Site Citation Adrien Picod, Jean-Michel Rebibou, Antoine Dossier, Bérengère Cador, David Ribes, Claire Vasco-Moynet, Caroline Stephan, Mathieu Bellal, Alain Wynckel, Pascale Poullin, Edwige Péju, Laure Ricard, Jean-Emmanuel Kahn, Raïda Bouzid, Ygal Benhamou, Bérangère Joly, Agnès Veyradier, Paul Coppo; Immune-mediated thrombotic thrombocytopenic purpura following COVID-19 vaccination. Blood 2022; 139 (16): 2565–2569. doi: https://doi.org/10.1182/blood.2021015149 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBlood Search Subjects: Clinical Trials and Observations, Free Research Articles, Thrombosis and Hemostasis TO THE EDITOR: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening form of thrombotic microangiopathy, which manifests by hemolytic anemia, consumptive thrombocytopenia, and diffuse microthrombi formation with organ damage resulting from a severe immune-mediated ADAMTS13 deficiency (activity below 10%).1 Recently, several cases of iTTP have been described after coronavirus disease 2019 (COVID-19) vaccination.2,3 These temporally associated events raise concerns about a potential causal link between vaccination and the development of the disease. Consequently, uncertainties persist regarding the best way to manage these cases as well as the approach to adopt in patients with known iTTP regarding vaccination. Finally, certain similarities with vaccine-induced thrombotic thrombocytopenia (VITT), a well-established complication of adenoviral vector–based vaccination,4 raise the question of the differential diagnosis between these 2 entities. The French Reference Center for Thrombotic Microangiopathies is a national network of French and... REFERENCES 1.Joly BS, Coppo P, Veyradier A. Thrombotic thrombocytopenic purpura. Blood. 2017;129(21):2836-2846.Google ScholarCrossrefSearch ADS PubMed 2.Maayan H, Kirgner I, Gutwein O, et al. Acquired thrombotic thrombocytopenic purpura: a rare disease associated with BNT162b2 vaccine. J Thromb Haemost. 2021;19(9):2314-2317.Google ScholarCrossrefSearch ADS PubMed 3.Giuffrida G, Condorelli A, Di Giorgio MA, et al. 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