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Local connectivity and synaptic dynamics in mouse and human neocortex

2022; American Association for the Advancement of Science; Volume: 375; Issue: 6585 Linguagem: Inglês

10.1126/science.abj5861

1095-9203

Luke Campagnola, Stephanie C. Seeman, Thomas Chartrand, Lisa Kim, Alex Hoggarth, Clare Gamlin, Shinya Ito, Jessica Trinh, Pasha A. Davoudian, Cristina Radaelli, Mean-Hwan Kim, Travis A Hage, Thomas Braun, Lauren Alfiler, Júlia Andrade, Phillip Bohn, Rachel Dalley, Alex M. Henry, Sara Kebede, Alice Mukora, David Sandman, Grace Williams, Rachael Larsen, Corinne Teeter, Tanya L. Daigle, Kyla Berry, Nadia Dotson, Rachel Enstrom, Melissa Gorham, Madie Hupp, Samuel Dingman Lee, Kiet Ngo, Philip R. Nicovich, Lydia Potekhina, Shea Ransford, Amanda Gary, Jeff Goldy, Delissa McMillen, Trangthanh Pham, Michael Tieu, La’Akea Siverts, Miranda Walker, Colin Farrell, Martin Schroedter, Cliff Slaughterbeck, Charles Cobb, Richard G. Ellenbogen, Ryder P. Gwinn, C. Dirk Keene, Andrew L. Ko, Jeffrey G. Ojemann, Daniel L. Silbergeld, Daniel Carey, Tamara Casper, Kirsten Crichton, Michael Clark, Nick Dee, Lauren Ellingwood, Jessica Gloe, Matthew Kroll, Josef Šulc, Herman Tung, Katherine Wadhwani, Krissy Brouner, Tom Egdorf, Michelle Maxwell, Mary McGraw, Christina Alice Pom, Augustin Ruiz, Jasmine Bomben, David Feng, Nika Hejazinia, Shi Shu, Aaron Szafer, Wayne Wakeman, John W. Phillips, Amy Bernard, Luke Esposito, Florence D. D’Orazi, Susan M. Sunkin, Kimberly A. Smith, Bosiljka Tasic, Anton Arkhipov, Staci A. Sorensen, Ed S. Lein, Christof Koch, Gabe Murphy, Hongkui Zeng, Tim Jarsky,

Neuroscience and Neural Engineering

We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct from those in the mouse cortex and vary with depth across layers 2 and 3.