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Prognostic value of right ventricular global longitudinal strain in transthyretin amyloid cardiomyopathy

2022; Elsevier BV; Volume: 80; Issue: 1 Linguagem: Inglês

10.1016/j.jjcc.2022.02.010

1876-4738

Hiroki Usuku, Seiji Takashio, Eiichiro Yamamoto, Toshihiro Yamada, Koichi Egashira, Mami Morioka, Masato Nishi, Takashi Komorita, Fumi Oike, Noriaki Tabata, Masanobu Ishii, Kenshi Yamanaga, Koichiro Fujisue, Daisuke Sueta, Yuichiro Arima, Satoshi Araki, Seitaro Oda, Yohei Misumi, Hiroaki Kawano, Kenichi Matsushita, Mitsuharu Ueda, Hirotaka Matsui, Kenichi Tsujita,

Parathyroid Disorders and Treatments

BackgroundThis study was performed to investigate whether right ventricular global longitudinal strain (RV-GLS) provides prognostic information in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM).Methods and resultsAmong 129 patients who were diagnosed with ATTRwt-CM at Kumamoto University Hospital from December 2002 to December 2019, 111 patients who had enough information for two-dimensional speckle tracking imaging were retrospectively analyzed. During a median follow-up of 615 days, 26 cardiovascular deaths occurred. Compared with patients in the non-event group, those in the cardiovascular death group were significantly older (81.1 ± 7.4 years vs. 78.2 ± 6.2 years, p = 0.009) and had significantly higher interventricular septal thickness in diastole (16.6 ± 3.1 mm vs. 15.3 ± 2.4 mm, p = 0.048), lower RV-GLS (10.9 ± 2.7% vs. 12.8 ± 3.5%, p = 0.010), and lower right ventricular free wall longitudinal strain (RVFWLS) (13.1 ± 3.3% vs. 15.5 ± 3.8%, p = 0.004). In the univariate Cox proportional hazard analysis, age, left atrial volume index (LAVI), RV-GLS, and RVFWLS were significantly associated with cardiovascular death [age, hazard ratio (HR), 1.10; 95% confidence interval (CI), 1.02–1.19, p = 0.010; LAVI, HR, 1.02; 95% CI, 1.00–1.03, p = 0.009; RV-GLS, HR, 0.86; 95% CI, 0.75–0.97, p = 0.017; RVFWLS, HR 0.89; 95% CI, 0.79–1.00; p = 0.041]. Multivariable Cox proportional hazard analysis showed RV-GLS was significantly and independently associated with cardiovascular death in patients with ATTRwt-CM (HR, 0.86; 95% CI, 0.74–0.99; p = 0.038). Receiver operating characteristic analysis showed that the area under the curve of RV-GLS for cardiovascular death was 0.668 and that the best cut-off value of RV-GLS was 11.59% (sensitivity, 69.2%; specificity, 63.5%). In the Kaplan–Meier analysis, patients with ATTRwt-CM who had low RV-GLS (<11.59%) had a significantly higher probability of total cardiovascular death (p = 0.004) and heart failure-related hospitalization (p = 0.013).ConclusionRV-GLS has significant prognostic value in patients with ATTRwt-CM and provides greater prognostic power than conventional echocardiographic findings.