Catalytic Asymmetric Benzylation of Azomethine Ylides Enabled by Synergistic Lewis Acid/Palladium Catalysis
2022; American Chemical Society; Volume: 24; Issue: 13 Linguagem: Inglês
10.1021/acs.orglett.2c00865
ISSN1523-7060
AutoresXin Chang, Jing-Di Ran, Xue‐Tao Liu, Chun‐Jiang Wang,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoThe synergistic chiral Lewis acid/achiral Pd catalyst system was successfully applied in the enantioselective benzylation of various imine esters, giving a range of α-benzyl-substituted α-amino acid derivatives in satisfactory yield with excellent enantioselectivity. It is worth noting that this strategy exhibits good tolerance for bicyclic and monocyclic benzylic electrophiles. Furthermore, the utility of this synthetic protocol was demonstrated by the expedient preparation of enantioenriched antihypertensive drug α-methyl-l-dopa.
Referência(s)