Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit
2022; eLife Sciences Publications Ltd; Volume: 11; Linguagem: Inglês
10.7554/elife.71094
ISSN2050-084X
AutoresBrogan Ashley, Claire Simner, Antigoni Manousopoulou, Carl Jenkinson, Felicity Hey, Jennifer M. Frost, Faisal I. Rezwan, Cory White, Emma M. Lofthouse, Emily Hyde, Laura Cooke, Sheila J. Barton, Pamela Mahon, Elizabeth Curtis, Rebecca J. Moon, Sarah Crozier, Hazel Inskip, Keith M. Godfrey, John W. Holloway, Cyrus Cooper, Kerry S. Jones, Rohan M. Lewis, Martin Hewison, Spiros D. Garbis, Miguel R. Branco, Nicholas C. Harvey, Jane K. Cleal,
Tópico(s)Cancer Risks and Factors
ResumoPregnancy 25-hydroxyvitamin D [25(OH)D] concentrations are associated with maternal and fetal health outcomes. Using physiological human placental perfusion and villous explants, we investigate the role of the placenta in regulating the relationships between maternal 25(OH)D and fetal physiology. We demonstrate active placental uptake of 25(OH)D
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