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The cognitive and psychiatric subacute impairment in severe Covid-19

2022; Nature Portfolio; Volume: 12; Issue: 1 Linguagem: Inglês

10.1038/s41598-022-07559-9

2045-2322

Pedro Jesús Serrano Castro, F.J. Garzón-Maldonado, Ignacio Casado-Naranjo, Angela Ollero-Ortiz, Adolfo Mínguez‐Castellanos, Mar Iglesias-Espinosa, P. Palomino, Violeta Sánchez Sánchez, Rosa María Sánchez-Pérez, José Rubi-Callejon, José Carlos Estévez-María, Benito Galeano-Bilbao, Jesús Romero-Imbroda, Beatriz Sobrino, Carlos Arrabal-Gomez, Begoña Oliver‐Martos, Luis Muñoz‐Becerra, Nerea Requena-Ocaña, María del Mar González Álvarez de Sotomayor, Guillermo Estivill‐Torrús, Juan Suárez, Nicolás Lundahl Ciano-Petersen, Gracia Pons-Pons, José Antonio Reyes-Bueno, Pablo Cabezudo‐García, María José Aguilar-Castillo, Carlos de la Cruz Cosme, María Duque-Holguera, Eva Cuartero-Rodriguez, Rosa María Vilches-Carrillo, Ismael Carrera-Muñoz, Cristóbal Carnero Pardo, Teresa Ramirez-García, Juan Manuel Oropesa, Ana Domínguez-Mayoral, Nazaret Pelaez-Viñas, Lucía Dolores Mesa Valiente, Fernando Rodrı́guez de Fonseca,

Intensive Care Unit Cognitive Disorders

Abstract Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective of this study is to analyze the selective involvement of the different cognitive domains and the existence of related biomarkers. Cross-sectional multicentric study of patients who survived severe infection with SARS-CoV-2 consecutively recruited between 90 and 120 days after hospital discharge. All patients underwent an exhaustive study of cognitive functions as well as plasma determination of pro-inflammatory, neurotrophic factors and light-chain neurofilaments. A principal component analysis extracted the main independent characteristics of the syndrome. 152 patients were recruited. The results of our study preferential involvement of episodic and working memory, executive functions, and attention and relatively less affectation of other cortical functions. In addition, anxiety and depression pictures are constant in our cohort. Several plasma chemokines concentrations were elevated compared with both, a non-SARS-Cov2 infected cohort of neurological outpatients or a control healthy general population. Severe Covid-19 patients can develop an amnesic and dysexecutive syndrome with neuropsychiatric manifestations. We do not know if the deficits detected can persist in the long term and if this can trigger or accelerate the onset of neurodegenerative diseases.