Portal de Periódicos da CAPES

Revisão Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Genetic variants associated with longitudinal changes in brain structure across the lifespan

2022; Nature Portfolio; Volume: 25; Issue: 4 Linguagem: Inglês

10.1038/s41593-022-01042-4

1546-1726

Rachel M. Brouwer, Marieke Klein, Katrina L. Grasby, Hugo G. Schnack, Neda Jahanshad, Jalmar Teeuw, Sophia I. Thomopoulos, Emma Sprooten, Carol E. Franz, Nitin Gogtay, William S. Kremen, Matthew S. Panizzon, Loes M. Olde Loohuis, Christopher D. Whelan, Moji Aghajani, Clara Alloza, Dag Alnæs, Éric Artiges, Rosa Ayesa‐Arriola, Gareth J. Barker, Mark E. Bastin, Elisabet Blok, Erlend Bøen, Isabella A. Breukelaar, Joanna K. Bright, Elizabeth E.L. Buimer, Robin Bülow, Dara M. Cannon, Simone Ciufolini, Nicolás Crossley, Christienne G. Damatac, Paola Dazzan, Casper L. de Mol, Sonja M. C. de Zwarte, Sylvane Desrivières, Covadonga M. Díaz‐Caneja, Nhat Trung Doan, Katharina Dohm, Juliane H. Fröhner, Janik Goltermann, Antoine Grigis, Dominik Grotegerd, Laura K. M. Han, Mathew A. Harris, Catharina A. Hartman, Sarah J. Heany, Walter Heindel, Dirk J. Heslenfeld, Sarah Hohmann, Bernd Ittermann, Philip R. Jansen, Joost Janssen, Tianye Jia, Jiyang Jiang, Christiane Jockwitz, Temmuz Karali, Daniel Keeser, Martijn Koevoets, Rhoshel Lenroot, Berend Malchow, René C.W. Mandl, Vicente Medel, Susanne Meinert, Catherine Morgan, Thomas W. Mühleisen, Leila Nabulsi, Nils Opel, Víctor Ortiz‐García de la Foz, Bronwyn J. Overs, Marie‐Laure Paillère Martinot, Ronny Redlich, Tiago Reis Marques, Jonathan Repple, Gloria Roberts, Gennady V. Roshchupkin, Nikita Setiaman, Elena Shumskaya, Frederike Stein, Gustavo Sudre, Shun Takahashi, Anbupalam Thalamuthu, Diana Tordesillas‐Gutiérrez, Aad van der Lugt, Neeltje E.M. van Haren, Joanna M. Wardlaw, Wei Wen, Henk‐Jan Westeneng, Katharina Wittfeld, Alyssa H. Zhu, André Zugman, Nicola J. Armstrong, Gaia Bonfiglio, Janita Bralten, Shareefa Dalvie, Gail Davies, Marta Di Forti, Linda Ding, Gary Donohoe, Andreas J. Forstner, Javier González‐Peñas, Joao Guimaraes, Georg Homuth, Jouke‐Jan Hottenga, Maria J. Knol, John B. Kwok, Stéphanie Le Hellard, Karen A. Mather, Yuri Milaneschi, Derek W. Morris, Markus M. Nöthen, Sergi Papiol, Marcella Rietschel, Marcos Santoro, Vidar M. Steen, Jason L. Stein, Fabian Streit, Rick M. Tankard, Alexander Teumer, Dennis van ‘t Ent, Dennis van der Meer, Kristel R. van Eijk, Evangelos Vassos, Javier Vázquez-Bourgón, Stephanie H. Witt, Rüdiger Brühl, Dimitri Papadopoulos Orfanos, Tomáš Paus, Sabina Millenet, Hieab H.H. Adams, Ingrid Agartz, David Ames, Katrin Amunts, Ole A. Andreassen, Celso Arango, Tobias Banaschewski, Bernhard T. Baune, Síntia Belangero, Arun L.W. Bokde, Dorret I. Boomsma, Rodrigo A. Bressan, Henry Brodaty, Jan K. Buitelaar, Wiepke Cahn, Svenja Caspers, Sven Cichon, Benedicto Crespo‐Facorro, Simon R. Cox, Udo Dannlowski, Torbjørn Elvsåshagen, Thomas Espeseth, Peter Falkai, Simon E. Fisher, Herta Flor, Janice M. Fullerton, Hugh Garavan, Penny Gowland, Hans J. Grabe, Tim Hahn, Andreas Heinz, Manon H. J. Hillegers, Jacqueline Hoare, Pieter J. Hoekstra, M. Arfan Ikram, Andrea Parolin Jackowski, Andreas Jansen, Erik G. Jönsson, René S. Kahn, Tilo Kircher, Mayuresh S. Korgaonkar, Axel Krug, Hervé Lemaître, Ulrik Fredrik Malt, Jean‐Luc Martinot, Colm McDonald, Philip B. Mitchell, Ryan L. Muetzel, Robin M. Murray, Frauke Nees, Igor Nenadić, Jaap Oosterlaan, Roel A. Ophoff, Pedro Mário Pan, Brenda W. J. H. Penninx, Luise Poustka, Perminder S. Sachdev, Giovanni Abrahão Salum, Peter R. Schofield, Günter Schumann, Philip Shaw, Kang Sim, Michael N. Smolka, Dan J. Stein, Julian N. Trollor, Leonard H. van den Berg, Jan H. Veldink, Henrik Walter, Lars T. Westlye, Robert Whelan, Tonya White, Margaret J. Wright, Sarah E. Medland, Barbara Franke, Paul M. Thompson, Hilleke E. Hulshoff Pol,

Birth, Development, and Health

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging. Human brain structure changes throughout the lifespan. Brouwer et al. identified genetic variants that affect rates of brain growth and atrophy. The genes are linked to early brain development and neurodegeneration and suggest involvement of metabolic processes.