Portal de Periódicos da CAPES

Prenatal trace elements mixture is associated with learning deficits on a behavioral acquisition task among young children

2022; Wiley; Volume: 2022; Issue: 181-182 Linguagem: Inglês

10.1002/cad.20458

1534-8687

Francheska M. Merced‐Nieves, John J. Chelonis, Ivan Pantic, Lourdes Schnass, Martha María Téllez‐Rojo, Joseph M. Braun, Merle G. Paule, Rosalind J. Wright, Robert O. Wright, Paul Curtin,

Heavy metals in environment

New Directions for Child and Adolescent DevelopmentEarly View RESEARCH ARTICLE Prenatal trace elements mixture is associated with learning deficits on a behavioral acquisition task among young children Francheska M. Merced-Nieves, Corresponding Author Francheska M. Merced-Nieves francheska.merced-nieves@mssm.edu orcid.org/0000-0003-0947-4029 Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA Correspondence Francheska M. Merced-Nieves, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Email: francheska.merced-nieves@mssm.eduSearch for more papers by this authorJohn Chelonis, John Chelonis Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USASearch for more papers by this authorIvan Pantic, Ivan Pantic Division of Community Interventions Research, National Institute of Perinatology, Mexico City, MexicoSearch for more papers by this authorLourdes Schnass, Lourdes Schnass Division of Community Interventions Research, National Institute of Perinatology, Mexico City, MexicoSearch for more papers by this authorMartha M. Téllez-Rojo, Martha M. Téllez-Rojo Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, MexicoSearch for more papers by this authorJoseph M. Braun, Joseph M. Braun Department of Epidemiology, Brown University, Providence, Rhode Island, USASearch for more papers by this authorMerle G. Paule, Merle G. Paule Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USASearch for more papers by this authorRosalind J. Wright, Rosalind J. Wright Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USASearch for more papers by this authorRobert O. Wright, Robert O. Wright Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USASearch for more papers by this authorPaul Curtin, Paul Curtin Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USASearch for more papers by this author Francheska M. Merced-Nieves, Corresponding Author Francheska M. Merced-Nieves francheska.merced-nieves@mssm.edu orcid.org/0000-0003-0947-4029 Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA Correspondence Francheska M. Merced-Nieves, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Email: francheska.merced-nieves@mssm.eduSearch for more papers by this authorJohn Chelonis, John Chelonis Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USASearch for more papers by this authorIvan Pantic, Ivan Pantic Division of Community Interventions Research, National Institute of Perinatology, Mexico City, MexicoSearch for more papers by this authorLourdes Schnass, Lourdes Schnass Division of Community Interventions Research, National Institute of Perinatology, Mexico City, MexicoSearch for more papers by this authorMartha M. Téllez-Rojo, Martha M. Téllez-Rojo Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, MexicoSearch for more papers by this authorJoseph M. Braun, Joseph M. Braun Department of Epidemiology, Brown University, Providence, Rhode Island, USASearch for more papers by this authorMerle G. Paule, Merle G. Paule Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USASearch for more papers by this authorRosalind J. Wright, Rosalind J. Wright Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USASearch for more papers by this authorRobert O. Wright, Robert O. Wright Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USASearch for more papers by this authorPaul Curtin, Paul Curtin Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USASearch for more papers by this author First published: 16 April 2022 https://doi.org/10.1002/cad.20458 This manuscript reflects the views of the author(s) and does not necessarily reflect those of the U.S. Food and Drug Administration. The research that was conducted at NCTR related to this manuscript was supported by protocol S00786. This work was reviewed by the FDA-IRB and was determined to be exempt because the FDA investigator had no access to any subject PHI. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Children are exposed to many trace elements throughout their development. Given their ubiquity and potential to have effects on children's neurodevelopment, these exposures are a public health concern. This study sought to identify trace element mixture-associated deficits in learning behavior using operant testing in a prospective cohort. We included 322 participants aged 6–7 years recruited in Mexico City with complete data on prenatal trace elements measurements (third trimester blood lead and manganese levels, and & urine cadmium and arsenic levels), demographic covariates, and the Incremental Repeated Acquisition (IRA), an associative learning task. Weighted quantile sum (WQS) regression models were used to estimate the joint association of the mixture of all four trace elements and IRA performance. Performance was adversely impacted by the mixture, with different elements relating to different aspects of task performance suggesting that prenatal exposure to trace element mixtures yields a broad dysregulation of learning behavior. Early ViewOnline Version of Record before inclusion in an issue RelatedInformation