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Hepato-pathological hallmarks for the surveillance of Yellow Fever in South American non-human primates

2022; Elsevier BV; Volume: 231; Linguagem: Inglês

10.1016/j.actatropica.2022.106468

1873-6254

Pedro H. O. Passos, Daniel Ramos, Alessandro Romano, Karina Ribeiro Leite Jardim Cavalcante, Luisa Helena Monteiro de Miranda, Janice Mery Chicarino Coelho, Ramona C. Barros, Arnaldo Jorge Martins Filho, Juarez Antônio Simões Quaresma, Isabel Luana de Macêdo, Taís Meziara Wilson, Davi Emanuel Ribeiro de Sousa, Cristiano Barros de Melo, Márcio Botelho de Castro,

Viral Infections and Outbreaks Research

The early detection and diagnosis of deaths in free-ranging non-human primates (NHPs) are key points for the surveillance of Yellow Fever (YF) in Brazil. The histopathological identification of infectious diseases remains very useful and reliable in the screening and detection of emerging zoonotic diseases such as YF. We surveyed data records and liver slides stained with hematoxylin and eosin from the Epizootics Surveillance Network to control YF, Ministry of Health of Brazil, to evaluate histopathological hallmarks for the diagnosis of the YF virus infection. We selected natural fatal cases in NHPs from the genera Alouatta spp., Callithrix spp., and Sapajus spp. with a positive immunohistochemical assay for YF in liver samples. Our findings showed the full-spectrum YF-associated hepatic lesions in all NHPs, but some histopathological findings differed in the distribution and intensity between the three genera. In our study, South American NHPs showed significant differences in the YF-associated hepatic histopathological features compared to fatal cases reported in humans.