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The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension

2022; Lippincott Williams & Wilkins; Volume: 130; Issue: 10 Linguagem: Inglês

10.1161/circresaha.121.320373

1524-4571

Lance Benson, Yunmeng Liu, Xiangting Wang, Yunzhao Xiong, Sung W. Rhee, Yunping Guo, Katherine Deck, Christoph Mora, Lin‐Xi Li, Lu Huang, J. Tucker Andrews, Zhiqiang Qin, Robert S. Hoover, Benjamin Ko, Ryan M. Williams, Daniel A. Heller, Edgar A. Jaimes, Shengyu Mu,

Atherosclerosis and Cardiovascular Diseases

Renal T cells contribute importantly to hypertension, but the underlying mechanism is incompletely understood. We reported that CD8Ts directly stimulate distal convoluted tubule cells (DCTs) to increase NCC (sodium chloride co-transporter) expression and salt reabsorption. However, the mechanistic basis of this pathogenic pathway that promotes hypertension remains to be elucidated.