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Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

2022; Elsevier BV; Volume: 21; Issue: 4 Linguagem: Inglês

10.1016/s1474-4422(22)00027-8

1474-4465

Estrella Morenas‐Rodríguez, Yan Li, Brigitte Nuscher, Nicolai Franzmeier, Chengjie Xiong, Marc Suárez‐Calvet, Anne M. Fagan, Stephanie A. Schultz, Brian A. Gordon, Tammie L.S. Benzinger, Jason Hassenstab, Eric McDade, Regina Feederle, Celeste M. Karch, Kai Schlepckow, John C. Morris, Gernot Kleinberger, Bengt Nellgård, Jonathan Vöglein, Kaj Blennow, Henrik Zetterberg, Michael Ewers, Mathias Jucker, Johannes Levin, Randall J. Bateman, Christian Haass, Sarah Adams, Ricardo Allegri, Aki Araki, Nicolas R. Barthélemy, Jacob Bechara, Sarah Berman, Courtney Bodge, Susan E. Brandon, William S. Brooks, Jared R. Brosch, Jill Buck, Virginia Buckles, Kathleen Carter, Lisa Cash, Charlie Chen, Jasmeer P. Chhatwal, Patricio Chrem, Jasmin Chua, Helena Chui, Carlos Cruchaga, Gregory S. Day, Chrismary De La Cruz, Darcy Denner, Anna Diffenbacher, Aylin Dincer, Tamara Donahue, Jane Douglas, Duc M. Duong, Noelia Egido, Bianca Esposito, Marty Farlow, Becca Feldman, Colleen Fitzpatrick, Shaney Flores, Nick C. Fox, Erin Franklin, Nelly Friedrichsen, Hisako Fujii, Samantha L. Gardener, Bernardino Ghetti, Alison Goate, Sarah B. Goldberg, Jill Goldman, Alyssa Gonzalez, Susanne Gräber‐Sultan, Neill Graff-Radford, Morgan Graham, Julia Gray, Emily Gremminger, Miguel L. Grilo, Alex Groves, Lisa M. Häsler, Cortaiga Hellm, Elizabeth Herries, Laura Hoechst-Swisher, Anna Hofmann, David M. Holtzman, Russ C. Hornbeck, Yakushev Igor, Ryoko Ihara, Takeshi Ikeuchi, Snežana Ikonomović, Kenji Ishii, Clifford Jack, Gina Jerome, Erik C. B. Johnson, Stephan Käser, Kensaku Kasuga, Sarah Keefe, William E. Klunk, Robert A. Koeppe, Deb Koudelis, Elke Kuder-Buletta, Christoph Laske, Allan I. Levey, Oscar L. López, Jacob I. Marsh, Rita Martinez, Ralph N. Martins, Neal Scott Mason, Colin L. Masters, Kwasi G. Mawuenyega, Austin McCullough, Arlene Mejia, James MountzMD, Cath Mummery, Neelesh K. Nadkarni, Akemi Nagamatsu, Katie Neimeyer, Yoshiki Niimi, James Noble, Joanne Norton, Brigitte Nuscher, Antoinette O’Connor, Ulricke Obermüller, Riddhi Patira, Richard J. Perrin, Lingyan Ping, Oliver Preische, Alan E. Renton, John M. Ringman, Stephen Salloway, Peter R. Schofield, Michio Senda, Nick Seyfried, Kristine Shady, Hiroyuki Shimada, Wendy Sigurdson, Jennifer A. Smith, Lori Smith, Beth E. Snitz, Hamid R. Sohrabi, Sochenda Stephens, Kevin Taddei, Sarah Thompson, Peter Wang, Qing Wang, Elise A. Weamer, Jinbin Xu, Xu Xiong,

Inflammation biomarkers and pathways

Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression of Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its effect on tau pathology and its potential beneficial role in people with Alzheimer's disease is still unclear. Our aim was to study associations between the dynamics of soluble TREM2, as a biomarker of TREM2 signalling, and amyloid β (Aβ) deposition, tau-related pathology, neuroimaging markers, and cognitive decline, during the progression of autosomal dominant Alzheimer's disease.