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Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma

2022; Cell Press; Volume: 39; Issue: 3 Linguagem: Inglês

10.1016/j.celrep.2022.110695

2639-1856

José R. Cortés, Ioan Filip, Robert Albero, Juan Ángel Patin͂o-Galindo, S. Aidan Quinn, Wen-Hsuan W. Lin, Anouchka P. Laurent, Bobby B. Shih, Jessie Brown, Anisha J. Cooke, Adam L. Mackey, Jonah Einson, Sakellarios Zairis, Alfredo Rivas‐Delgado, Maria Antonella Laginestra, Stefano Pileri, Elı́as Campo, Govind Bhagat, Adolfo A. Ferrando, Raúl Rabadán, Teresa Palomero,

Cancer Immunotherapy and Biomarkers

Peripheral T cell lymphoma not otherwise specified (PTCL-NOS) comprises heterogeneous lymphoid malignancies characterized by pleomorphic lymphocytes and variable inflammatory cell-rich tumor microenvironment. Genetic drivers in PTCL-NOS include genomic alterations affecting the VAV1 oncogene; however, their specific role and mechanisms in PTCL-NOS remain incompletely understood. Here we show that expression of Vav1-Myo1f, a recurrent PTCL-associated VAV1 fusion, induces oncogenic transformation of CD4