Extracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome
2022; National Academy of Sciences; Volume: 119; Issue: 17 Linguagem: Inglês
10.1073/pnas.2107394119
ISSN1091-6490
AutoresMercedes Tkach, Jessie Thalmensi, Eleonora Timperi, Paul Gueguen, Nathalie Névo, Eleonora Grisard, Philémon Sirven, Federico Cocozza, Alizée Gouronnec, Lorena Martín‐Jaular, Mabel Jouve, Fabien Delisle, Nicolas Manel, Derek C. Rookhuizen, Coralie L. Guérin, Vassili Soumelis, Emanuela Romano, Elodie Ségura, Clotilde Théry,
Tópico(s)Reproductive System and Pregnancy
ResumoSignificance Our work uncovers mechanisms by which tumor cells impact tumor-associated macrophages in human triple-negative breast cancer. Via extracellular vesicles (EVs), these tumors promote macrophages with proinflammatory features, correlated with better clinical outcome. Our results suggest exploration of these EVs as tools, alone, or in combination with other therapies, to promote a favorable environment for the generation of anti-tumor immune responses.
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