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Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry

2022; Springer Science+Business Media; Volume: 17; Issue: 6 Linguagem: Inglês

10.1007/s11739-022-02980-4

1970-9366

Alfredo De Giorgi, Alberto M. Marra, Massimo Iacoviello, Vincenzo Triggiani, Giuseppe Rengo, Francesco Cacciatore, Ciro Maiello, Giuseppe Limongelli, Daniele Masarone, Francesco Perticone, Pasquale Perrone Filardi, Stefania Paolillo, Antonio Mancini, Maurizio Volterrani, Olga Vriz, Roberto Castello, Andrea Passantino, Michela Campo, Pietro Amedeo Modesti, Andrea Salzano, Roberta D’Assante, Michele Arcopinto, Valeria Raparelli, Fabio Fabbian, Angela Sciacqua, Annamaria Colao, Toru Suzuki, Eduardo Bossone, Antonio Cittadini, Antonio Cittadini, M. A. ArcopintoSalzano, Luigi Saccà, M. Monti, Raffaele Napoli, Margherita Matarazzo, Francesca M. Stagnaro, Alessandra Schiavo, Pedro Valente, Eduardo Bossone, Francesco Ferrara, Valentina Russo, M. Malinconico, Rodolfo Citro, E. Guastalamacchia, Massimo Iacoviello, Marta Leone, Vincenzo Triggiani, Francesco Cacciatore, Ciro Maiello, Cristiano Amarelli, I. Mattucci, Giuseppe Limongelli, Daniele Masarone, Paolo Calabrò, R. Calabrò, Antonello D’Andrea, V. Maddaloni, Giuseppe Pacileo, R. Scarafile, Francesco Perticone, A. Belfiore, Angela Sciacqua, Antonio Cimellaro, Pasquale Perrone Filardi, Laura Casaretti, Stefania Paolillo, Paola Gargiulo, Antonio Mancini, Angela Favuzzi, C. Di Segni, Carmine Bruno, Edoardo Vergani, Olga Vriz, Roberto Castello, Anna Chiara Frigo, Michela Campo, M. R. Sorrentino, Pietro Amedeo Modesti, D. Malandrino, Roberto Manfredini, Alfredo De Giorgi, Fabio Fabbian, A Puzzo, L. Ragusa, Luigi Caliendo, Laura Carbone, Alessandro Frigiola, T. Generali, F. Giacomazzi, Carlo De Vincentiis, Andrea Ballotta, P. Garofalo, Graziella Malizia, Toru Suzuki, Liam M. Heaney, Dario Bruzzese,

Hyperglycemia and glycemic control in critically ill and hospitalized patients

Data from the "Trattamento Ormonale nello Scompenso CArdiaco" (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry.At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we evaluate the effects of renal function on the CVM.337 patients (41 deceased) were analyzed. CVM was related to severe renal dysfunction (HR stages IV-V = 4.86), high-risk conditions (HR 2.25), serum IGF-1 (HR 0.42), and HF etiology (HR 5.85 and HR 1.63 for valvular and ischemic etiology, respectively). In high-risk patients, CVM was related to IGF-1 levels, severe renal dysfunction and valvular etiology, whereas in young patients CMV was related to the high-risk pattern and serum IGF-1 levels.Our study showed the clinical and prognostic utility of the IGF-1 assay in patients with HF.