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Incidence Rates and Clinical Outcomes of SARS-CoV-2 Infection With the Omicron and Delta Variants in Children Younger Than 5 Years in the US

2022; American Medical Association; Volume: 176; Issue: 8 Linguagem: Inglês

10.1001/jamapediatrics.2022.0945

2168-6211

Lindsey Wang, Nathan A. Berger, David C. Kaelber, Pamela B. Davis, Nora D. Volkow, Rong Xu,

Long-Term Effects of COVID-19

Incidence Rates and Clinical Outcomes of SARS-CoV-2 Infection With the Omicron and Delta Variants in Children Younger Than 5 Years in the US With the Omicron variant (B.1.1.529),SARS-CoV-2 infections and hospitalizations reached record levels. 1 Children younger than 5 years may be especially vulnerable because they are not eligible for COVID-19 vaccination. 2We examined incidence rates and clinical outcomes of Omicron infection before and after Omicron became the predominant variant in the US.Methods | This cohort study (September 1, 2021-January 31, 2022) was approved by the MetroHealth System institutional review board (IRB); the need for informed consent was waived owing to use of deidentified patient data.We used the Tri-NetX Analytics Platform to access aggregated and deidentified electronic health records of 90 million patients from 66 health care organizations.TriNetX built-in analytic functions permit patientlevel analyses while only reporting population-level data.Patients represented 28% of the US population from 50 states covering diverse geographic, age, race, income, and insurance groups. 3Self-identified race and ethnicity were included owing to their association with SARS-CoV-2 infection risk and outcomes. Supplemental contentTable.Characteristics of the Omicron Cohort and the Delta Cohort Before and After Propensity Matching a Characteristic Before matching After matching Cohort, No. (%) SMD Cohort, No. (%)