Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts
2022; Radiological Society of North America; Volume: 304; Issue: 2 Linguagem: Inglês
10.1148/radiol.210363
ISSN1527-1315
AutoresAbhaya Trivedi, Chase Hall, Charles W. Goss, Daphne Lew, J.G. Krings, M.C. McGregor, M. Samant, Jered Sieren, Huashi Li, Ken B. Schechtman, Joshua Schirm, Stephen McEleney, S. Peterson, Wendy C. Moore, Eugene R. Bleecker, Deborah A. Meyers, Elliot Israel, George R. Washko, Bruce D. Levy, Joseph K. Leader, Sally E. Wenzel, John V. Fahy, Mark L. Schiebler, Sean B. Fain, Nizar N. Jarjour, David T. Mauger, Joseph M. Reinhardt, John D. Newell, Eric A. Hoffman, Mario Castro, Ajay Sheshadri, Elliot Israel, Bruce D. Levy, Manuela Cernadas, George R. Washko, Kathleen J. Haley, Juan Carlos Cardet, Melody G. Duvall, Victoria E. Forth, Meghan Le, Eva Fandozzi, Allison F. O’Neill, Katarina Gentile, Maria Cinelli, Abigail Tulchinsky, Guilberto Lawrance, Randall Czajkowski, Peter Lemole, William Antunes, Ann D. McGinnis, Kris Klokeid, Wanda Phipatanakul, William J. Sheehan, Lisa Bartnikas, Sachin N. Baxi, Elena Crestani, Brittany Etsy, Jonathan M. Gaffin, Marissa Hauptman, David Kantor, Peggy S. Lai, Margee Louisias, Kyle A. Nelson, Perdita Permaul, Lynda C. Schneider, Lakiea S. Wright, Samantha Minnicozzi, Michelle C. Maciag, Mehtap Haktanir-Abul, Sigfus Gunnlaugsson, Elizabeth Burke‐Roberts, Amparito Cunningham, Ethan Ansel-Kelly, Sullivan Waskosky, Anna Ramsey, Laura Feloney, Sally E. Wenzel, Merritt L. Fajt, Juan C. Celedón, Allyson Larkin, Y. Peter Di, Hong Wei Chu, Marc Gauthier, Wei Wu, S. Jain, Matthew Camiolo, Christine Rauscher, Faith S. Luyster, Paul Rebovich, Jessa Demas, Renee Wunderley, Catherine A. Vitari, Melissa Ilnicki, Diane Srollo, Crystal Takosky, Rose Lanzo, Joseph K. Leader, Daniel M. Lapic, Emily Etling, Donna H. Rhodes, Jeananne Burger, Erin Glover, Albert J. Peters, Carl H. Smith, Nicholas Bonfiglio, John B. Trudeau, Seojin Bang, Qiao Lin, Chia-Hsin Liu, Saran Kupul, Nizar N. Jarjour, Loren C. Denlinger, Robert F. Lemanske, Sean B. Fain, Ravi Viswanathan, Mark B. Moss, Dan Jackson, Ronald L. Sorkness, Sima Ramratnam, Matthew C. Tattersall, Gina Crisafi, Danika Klaus, Lori Wollet, Julia Bach, Mats W. Johansson, Mark L. Schiebler, Stéphane Esnault, Sameer K. Mathur, Jan Yakey, Heather Floerke, Arturo Guadarrama, Andrew Maddox, Brooke Peters, Katelin Beaman, Kaharu Sumino, Mario Castro, Leonard B. Bacharier, David S. Gierada, Jason C. Woods, Kenneth B. Schechtman, Brenda Patterson, Ajay Sheshadri, Andrea M. Coverstone, Adrian Shifren, James D. Quirk, Derek E. Byers, J.G. Krings, M.C. McGregor, M. Samant, Jaime Tarsi, Tammy Koch, Vanessa Curtis, Huiqing Yin‐Declue, Jonathan Boomer, Melissa Saylor, Shirley Frei, Licia Rowe, Geneline Sajol, Jim Kozlowski, Eric A. Hoffman, Elizabeth Allard, Jarron Atha, Lin Ching-Long, John V. Fahy, Prescott G. Woodruff, Ngoc P. Ly, Nirav R. Bhakta, Michael C. Peters, Courtney C. Moreno, Ariana Baum, Donna Liu, Anjali Kalra, Xavier Orain, Annabelle R. Charbit, Ndidi Njoku, Eleanor M. Dunican, W. Gerald Teague, Roby Greenwald, Mark D. DeBoer, Kristin Wavell, Kimberly deRonde, Serpil C. Erzurum, John Carl, Sumita Khatri, Raed A. Dweik, Suzy Comhair, Jackie Sharp, Jason K. Lempel, Samar Farha, Rachel M. Taliercio, Mark Aronica, Joe Zein, Michelle S. Koo, Tracy A. Painter, Kim Hopkins, Joy Lawrence, Simon Abi-Saleh, Monica Labadia, Elion Qirjaz, Ron Wehrmann, Debera Arbruster, Teresa Markle, Brittany Matuska, Sara Baicker-McKee, Patrick Wyszynski, Kelly N. Fitzgerald, Kristie Ross, Benjamin Gaston, Ross Myers, Daniel Craven, Erica A. Roesch, Ryan M. Thomas, Laurie Logan, Laura Veri, Adam Gluvna, Julie Wallace, Margaret Pryor, Sara Smith, Patricia Allerton, Traci Emrich, Jay B. Hilliard, Jeanne E. Krenicky, Laura Smith, Matthew Ferrebee, Wendy C. Moore, Eugene R. Bleecker, Deborah A. Meyers, Stephen P. Peters, Xingnan Li, Annette T. Hastie, Victor E. Ortega, Greg Hawkins, Jeff Krings, Elizabeth J. Ampleford, Anna Pippins, Paige Field, Brian Rector, Ryan Sprissler, Barbara Fransway, Anne M. Fitzpatrick, Susan T. Stephenson, David T. Mauger, Brenda R. Phillips,
Tópico(s)Inhalation and Respiratory Drug Delivery
ResumoBackground Clustering key clinical characteristics of participants in the Severe Asthma Research Program (SARP), a large, multicenter prospective observational study of patients with asthma and healthy controls, has led to the identification of novel asthma phenotypes. Purpose To determine whether quantitative CT (qCT) could help distinguish between clinical asthma phenotypes. Materials and Methods A retrospective cross-sectional analysis was conducted with the use of qCT images (maximal bronchodilation at total lung capacity [TLC], or inspiration, and functional residual capacity [FRC], or expiration) from the cluster phenotypes of SARP participants (cluster 1: minimal disease; cluster 2: mild, reversible; cluster 3: obese asthma; cluster 4: severe, reversible; cluster 5: severe, irreversible) enrolled between September 2001 and December 2015. Airway morphometry was performed along standard paths (RB1, RB4, RB10, LB1, and LB10). Corresponding voxels from TLC and FRC images were mapped with use of deformable image registration to characterize disease probability maps (DPMs) of functional small airway disease (fSAD), voxel-level volume changes (Jacobian), and isotropy (anisotropic deformation index [ADI]). The association between cluster assignment and qCT measures was evaluated using linear mixed models. Results A total of 455 participants were evaluated with cluster assignments and CT (mean age ± SD, 42.1 years ± 14.7; 270 women). Airway morphometry had limited ability to help discern between clusters. DPM fSAD was highest in cluster 5 (cluster 1 in SARP III: 19.0% ± 20.6; cluster 2: 18.9% ± 13.3; cluster 3: 24.9% ± 13.1; cluster 4: 24.1% ± 8.4; cluster 5: 38.8% ± 14.4;
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