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Persistence of long-term COVID-19 sequelae in patients with cancer: An analysis from the OnCovid registry

2022; Elsevier BV; Volume: 170; Linguagem: Inglês

10.1016/j.ejca.2022.03.019

1879-0852

Alessio Cortellini, Ramón Salazar, Alessandra Gennari, Juan Aguilar‐Company, Mark Bower, Alexia Bertuzzi, Joan Brunet, Matteo Lambertini, Clara Maluquer, Paolo Pedrazzoli, Alvin Lee, M. Carmen Carmona-García, Thomas Newsom-Davis, Mieke Van Hemelrijck, Andrea Plaja, Alberto Zambelli, Carlo Tondini, Daniele Generali, Rossella Bertulli, Nikolaos Diamantis, Uma Mukherjee, Gianpiero Rizzo, Tamara Yu, Federica Zoratto, Riccardo Bruna, Anna Sureda, Clara Martínez-Vila, Luca Cantini, Francesca Mazzoni, Federica Grosso, Alessandro Parisi, Maristella Saponara, Aleix Prat, David J. Pinato,

Intensive Care Unit Cognitive Disorders

IntroductionA significant proportion of patients with cancer who recover from Coronavirus Disease 2019 (COVID-19) may experience COVID-19 sequelae in the early post-infection phase, which negatively affect their continuity of care and oncological outcome. The long-term prevalence and clinical impact of the post-COVID-19 syndrome in patients with cancer are largely unknown.MethodsIn this study, we describe the time course of COVID-19 sequelae in patients with non-advanced cancers enrolled in the OnCovid registry.ResultsOverall, 186 patients were included, with a median observation period of 9.9 months (95%CI:8,8–11.3) post-COVID-19 resolution. After a median interval of 2.3 months post-COVID-19 (interquartile range: 1.4–3.7), 31 patients (16.6%) reported ≥1 sequelae, including respiratory complications (14, 7.6%), fatigue (13, 7.1%), neuro-cognitive sequelae (7, 3.8%). The vast majority of the patients were not vaccinated prior to COVID-19. COVID-19-related sequelae persisted in 9.8% and 8% of patients 6 and 12 months after COVID-19 resolution. Persistence of sequelae at first oncological follow-up was associated with history of complicated COVID-19 (45.2% vs 24.8%, p = 0.0223), irrespective of oncological features at COVID-19 diagnosis.ConclusionThis study confirms for the first time that, in a largely unvaccinated population, post-COVID-19 syndrome can affect a significant proportion of patients with non-advanced cancer who recovered from the acute illness. COVID-19 sequelae may persist up to 12 months in some patients, highlighting the need for dedicated prevention and supportive strategies.