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Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study

2022; Elsevier BV; Volume: 399; Issue: 10332 Linguagem: Inglês

10.1016/s0140-6736(22)00462-7

1474-547X

Tommy Nyberg, Neil M. Ferguson, Sophie Nash, Harriet Webster, Seth Flaxman, Nick Andrews, Wes Hinsley, Jamie Lopez Bernal, Meaghan Kall, Samir Bhatt, Paula Blomquist, Asad Zaidi, Erik Volz, Nurin Abdul Aziz, Katie Harman, Sebastian Funk, Sam Abbott, Russell Hope, André Charlett, Meera Chand, Azra C. Ghani, Shaun R. Seaman, Gavin Dabrera, Daniela De Angelis, Anne M. Presanis, Simon Thelwall, Tommy Nyberg, Neil M. Ferguson, Sophie Nash, Harriet Webster, Seth Flaxman, Nick Andrews, Wes Hinsley, Jamie Lopez Bernal, Meaghan Kall, Samir Bhatt, Paula Blomquist, Asad Zaidi, Erik Volz, Nurin Abdul Aziz, Katie Harman, Sebastian Funk, Sam Abbott, Russell Hope, André Charlett, Meera Chand, Azra C. Ghani, Shaun R. Seaman, Gavin Dabrera, Daniela De Angelis, Anne M. Presanis, Simon Thelwall,

SARS-CoV-2 detection and testing

The omicron variant (B.1.1.529) of SARS-CoV-2 has demonstrated partial vaccine escape and high transmissibility, with early studies indicating lower severity of infection than that of the delta variant (B.1.617.2). We aimed to better characterise omicron severity relative to delta by assessing the relative risk of hospital attendance, hospital admission, or death in a large national cohort.