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Cumulative Incidence and Risk Factors for Severe Coronavirus Disease 2019 in French People With Cystic Fibrosis

2022; Oxford University Press; Volume: 75; Issue: 12 Linguagem: Inglês

10.1093/cid/ciac333

1537-6591

Harriet Corvol, Sandra de Miranda, Clémence Dehillotte, Lydie Lemonnier, R. Chiron, Isabelle Danner‐Boucher, Rébecca Hamidfar, Véronique Houdouin, Julie Macey, Christophe Marguet, M. Murris‐Espin, Quitterie Reynaud, Philippe Reix, Martine Reynaud Gaubert, Astrid Kemgang, Pierre‐Régis Burgel, M. Abély, Nathalie Allou, Baptiste Arnouat, Carole Bailly Piccini, Chantal Belleguic, Tiphaine Bihouée, Yves Billon, S. Bui, Pierre‐Régis Burgel, B. Camara, M Héraud, R. Chiron, Emmanuelle Coirier Duet, Harriet Corvol, Laure Cosson, Isabelle Danner‐Boucher, Sandra de Miranda, Eric Deneuville, David Drummond, J.‐C. Dubus, I. Durieu, Ralph Epaud, M. Gérardin, Dominique Grenet, Véronique Houdouin, Frédéric Huet, Reem Kanaan, Romain Kessler, Alice Ladaurade, Jeanne Languepin, Muriel Laurans, Olivier Le Rouzic, Sylvie Leroy, Cathie Llerena, Julie Macey, Julie Mankikian, Christophe Marguet, C. Martín, Laurent Mély, M. Mittaine, M. Murris‐Espin, Caroline Périsson, Anne Prévötat, Sophie Ramel, Cinthia Rames, Philippe Reix, Marine Revillion, Martine Reynaud‐Gaubert, Bénédicte Richaud-Thiriez, Manuëla Scalbert-Dujardin, Isabelle Sermet‐Gaudelus, V. Storni, Aurélie Tatopoulos, Guillaume Thouvenin, Françoise Troussier, Laurence Weiss, Nathalie Wizla,

Respiratory viral infections research

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are closely monitored in people with cystic fibrosis (pwCF), especially severe cases. Previous studies used hospitalization rates as proxy for severity. Methods We evaluated data from coronavirus disease 2019 (COVID-19) cases diagnosed in French pwCF over the first pandemic year. Objective criteria were applied for defining severity (eg, respiratory failure and/or death). Data were compared to all French pwCF using the National Registry. Results As of 30 April 2021, 223 pwCF were diagnosed with COVID-19, with higher risks in adults (odds ratio [OR], 2.52 [95% confidence interval {CI}, 1.82−3.48]) and transplant recipients (OR, 2.68 [95% CI, 1.98–3.63]). Sixty (26.9%) patients were hospitalized, with increased risk in transplant recipients (OR, 4.74 [95% CI, 2.49–9.02]). In 34 (15%) cases, COVID-19 was considered severe; 28 (46.7%) hospitalizations occurred without objective criteria of severity. Severe cases occurred mostly in adult (85.3%) and posttransplant pwCF (61.8%; OR, 6.02 [95% CI, 2.77–13.06]). In nontransplanted pwCF, risk factors for severity included low lung function (median percentage of predicted forced expiratory volume in 1 second, 54.6% vs 75.1%; OR, 1.04 [95% CI, 1.01–1.08]) and CF-related diabetes (OR, 3.26 [95% CI, 1.02–10.4]). While 204 cases fully recovered, 16 were followed for possible sequelae, and 3 posttransplant females died. Conclusions Severe COVID-19 occurred infrequently during the first pandemic year in French pwCF. Nontransplanted adults with severe respiratory disease or diabetes and posttransplant individuals were at risk for severe COVID-19. Thus, specific preventive measures should be proposed.