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One-Year Sequelae and Quality of Life in Adults with Meningococcal Meningitis: Lessons from the COMBAT Multicentre Prospective Study

2022; Adis, Springer Healthcare; Volume: 39; Issue: 6 Linguagem: Inglês

10.1007/s12325-022-02149-7

1865-8652

Xavier Duval, Muhamed‐Kheir Taha, I. Lamaury, L. Escaut, I. Gueït, Pauline Manchon, Sarah Tubiana, Bruno Hoen, Xavier Duval, Bruno Hoen, Bruno Mourvillier, Marie-Cécile Ploy, Sarah Tubiana, Emmanuelle Varon, François Caron, Pierre‐Édouard Bollaert, Olivier Gaillot, Muhamed‐Kheir Taha, Claire Poyart, Stéphane Bonacorsi, François Vandenesch, Emmanuelle Cambau, Marc Lecuit, Alain Gravet, Bruno Frachet, T. de Broucker, D Lévy-Brühl, François Raffi, Marie Préau, Nadia Anguel, Laurent Argaud, S. Arista, Laurence Armand-Lefevre, Stéphanie Balavoine, Régine Baraduc, Guilène Barnaud, Guillaume Béraud, Louis Bernard, Georges Bernars, Dominique Bertei, Emilie Bessède, Typhaine Billard Pomares, Charlotte Biron, Stéphane Bland, J. Boileau, Patrice Boubeau, Sandra Bourdon, Aurore Bousquet, Sophie Boyer, A. Bozorg–Grayeli, Laurent Bret, Cédric Bretonnière, François Bricaire, Elsa Brocas, Michel Brun, J. Buret, Christophe Burucoa, Jean Cabalion, Mathieu Cabon, Emmanuelle Cambau, G. Camuset, Christophe Canevet, François Caron, Anne Carricajo, Bernard Castan, Éric Caumes, Charles Cazanave, Amélie Chabrol, T. Challan-Belval, Vanessa Chanteperdrix-Marillier, C. Chaplain, Caroline Charlier-Woerther, H. Chaussade, Catherine Chirouze, Bernard Clair, Julien Colot, Jean‐Marie Conil, Hugues Cordel, Philippe Cormier, Joël Cousson, Pierrick Cronier, Éric Cua, Anne Dao-Dubremetz, S. Dargère, Nicolas Degand, S. Dekeyser, Déborah Delaune, E. Denès, Pierre‐François Dequin, Diane Descamps, Élodie Descloux, Jean-Luc Desmaretz, Jean‐Luc Diehl, Jérôme Dimet, Aurélien Dinh Xavier Duval, L. Escaut, Claude Fabe, F. Faibis, C. Flateau, Nathalie Fonsale, E. Forestier, Nicolas Fortineau, Amandine Gagneux‐Brunon, Caroline Garandeau, Magali Garcia, Denis Garot, Stéphane Gaudry, François Goehringer, Alain Gravet, Valérie Gregoire-Faucher, Marine Grosset, C. Gubavu, I. Gueït, D. Guélon, Thomas Guimard, Jérôme Guinard, Tahar Hadou, Jean-Pierre Helene, Sandrine Henard, Benoît Henry, Anne-Cécile Hochart, Bruno Hoen, Gabriela Illes, S. Jaffuel, Irène Jarrin, Françoise Jauréguy, Cédric Joseph, Marie-Emmanuelle Juvin, Samer Kayal, Solen Kernéis, F. Lacassin, I. Lamaury, Philippe Lanotte, E. Laurens, H. Laurichesse, Cécile Le Brun, Vincent Le Moing, Paul Le Turnier, Hervé Lécuyer, Sylvie Ledru, Céline Legrix, Adrien Lemaignen, Chantal Lemblé, Ludovic Lemée, O. Lesens, Marion Levast, Claire Lhommet, S. Males, Edith Malpote, Guillaume Martin‐Blondel, Matthieu Marx, Raphaël Masson, Olivier Matray, Aurore Mbadi, F. Méchaï, Guillaume Mellon, Audrey Mérens, M.C. Meyohas, Adrien Michon, Joy Mootien Yoganaden, David Morquin, Stéphane Mouly, Natacha Mrozek, Sophie Nguyen, Yohan N’Guyen, Maja Ogielska, E. Oziol, Bernard Page, S. Patrat-Delon, Isabelle Patry, A. Péchinot, Stéphane Picot, Denys Pierrejean, Lionel Piroth, Claire Plassart, Patrice Plessis, Marie-Cécile Ploy, L. Portel, P. Poubeau, Marie Poupard, Claire Poyart, Thiérry Prazuck, Luc Quaesaet, François Raffi, Adriatsiferana Ramanantsoa, C. Rapp, Laurent Raskine, Josette Raymond, Matthieu Revest, Agnès Riché, Stéphanie Robaday-Voisin, Frédéric Robin, J.‐P. Romaszko, Florence Rousseau, Anne‐Laure Roux, Cécile Royer, Matthieu Saada, Dominique Salmon, Carlo Saroufim, Jean Luc Schmit, Manuela Sébire, Christine Segonds, Valérie Sivadon‐Tardy, Nathalie Soismier, Olivia Son, Simon Sunder, Florence Suy, Didier Tandé, Jacques Tankovic, Nadia Valin, Nicolas Van Grunderbeeck, François Vandenesch, Emmanuelle Varon, Renaud Verdon, M. Vergnaud, Véronique Vernet-Garnier, M. Vidal, Virginie Vitrat, Daniel Vittecoq, Fanny Vuotto, Isabelle Gorenne, Cédric Laouénan, Pauline Manchon, Estelle Marcault, France Mentré, Blandine Pasquet, Carine Roy, Sarah Tubiana,

Respiratory viral infections research

COMBAT is a prospective, multicentre cohort study that enrolled consecutive adults with community-acquired bacterial meningitis (CABM) in 69 participating centres in France between February 2013 and July 2015 and followed them for 1 year. Patients aged at least 18 years old, hospitalised with CABM were followed during their hospitalisation and then contacted by phone 12 months after enrolment. Here we present the prevalence of sequelae at 12 months in a subgroup of patients with meningococcal meningitis. Five of the 111 patients with meningococcal meningitis died during initial hospitalisation and two died between discharge and 12 months, leaving 104 patients alive 1 year after enrolment, 71 of whom provided 12-month follow-up data. The median age was 30.0 years and 54.1% of the patients had no identified risk factor for meningitis. More than 30% reported persistent headache, more than 40% were not satisfied with their sleep and 10% had concentration difficulties. Hearing loss was present in about 15% of the patients and more than 30% had depressive symptoms. About 13% of the patients with a previous professional activity had not resumed work. On the SF-12 Health Survey, almost 50% and 30% had physical component or mental component scores lower than the 25th percentile of the score distribution in the French general population. There was a non-significant improvement in the patients' disability scores from hospital discharge to 12 months (p = 0.16), but about 10% of the patients had residual disability. Although most patients in our cohort survive meningococcal meningitis, the long-term burden is substantial and therefore it is important to ensure a prolonged follow-up of survivors and to promote preventive strategies, including vaccination. ClinicalTrial.Gov identification number NCT01730690.