Portal de Periódicos da CAPES

Ripple-selective GABAergic projection cells in the hippocampus

2022; Cell Press; Volume: 110; Issue: 12 Linguagem: Inglês

10.1016/j.neuron.2022.04.002

1097-4199

Gergely Szabó, Jordan S. Farrell, Barna Dudok, Wen‐Hsien Hou, Anna L. Ortiz, Csaba Varga, Prannath Moolchand, Cafer İkbal Gülsever, Tilo Gschwind, Jordane Dimidschstein, Marco Capogna, Iván Soltész,

Neuroinflammation and Neurodegeneration Mechanisms

Ripples are brief high-frequency electrographic events with important roles in episodic memory. However, the in vivo circuit mechanisms coordinating ripple-related activity among local and distant neuronal ensembles are not well understood. Here, we define key characteristics of a long-distance projecting GABAergic cell group in the mouse hippocampus that selectively exhibits high-frequency firing during ripples while staying largely silent during theta-associated states when most other GABAergic cells are active. The high ripple-associated firing commenced before ripple onset and reached its maximum before ripple peak, with the signature theta-OFF, ripple-ON firing pattern being preserved across awake and sleep states. Controlled by septal GABAergic, cholinergic, and CA3 glutamatergic inputs, these ripple-selective cells innervate parvalbumin and cholecystokinin-expressing local interneurons while also targeting a variety of extra-hippocampal regions. These results demonstrate the existence of a hippocampal GABAergic circuit element that is uniquely positioned to coordinate ripple-related neuronal dynamics across neuronal assemblies.