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BIBTEX RIS

Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response

2022; BioMed Central; Volume: 14; Issue: 1 Linguagem: Inglês

10.1186/s13073-022-01050-w

ISSN

1756-994X

Autores

Zhen Zhang, Zixian Wang, Yan‐Xing Chen, Hao‐Xiang Wu, Ling Yin, Qi Zhao, Hui Luo, Zhao-Lei Zeng, Miao‐Zhen Qiu, Rui‐Hua Xu,

Tópico(s)

Single-cell and spatial transcriptomics

Resumo

Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the potential culprit in ICI resistance, but direct clinical evidence is lacking.

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