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MP54-13 THE UPDATE FROM BLADDER CANCER ITALIAN ACTIVE SURVEILLANCE (BIAS) PROJECT FOR LOW-GRADE BLADDER TUMORS: LONG-TERM ONCOLOGICAL OUTCOMES OF PATIENTS UNDER ACTIVE SURVEILLANCE

2022; Lippincott Williams & Wilkins; Volume: 207; Issue: Supplement 5 Linguagem: Inglês

10.1097/ju.0000000000002633.13

1527-3792

Edoardo Beatrici, Roberto Contieri, Nicola Frego, Vittorio Fasulo, Pietro Diana, Marco Paciotti, Davide Maffei, Pier Paol Avolio, Alessandro Uleri, Cesare Saitta, Paola Arena, Giuseppe Chiarelli, Andrea Gobbo, Nicolò Maria Buffi, Massimo Lazzeri, Paolo Casale, Alberto Saita, Giorgio Guazzoni, Giovanni Lughezzani, Rodolfo Hurle,

Renal cell carcinoma treatment

You have accessJournal of UrologyCME1 May 2022MP54-13 THE UPDATE FROM BLADDER CANCER ITALIAN ACTIVE SURVEILLANCE (BIAS) PROJECT FOR LOW-GRADE BLADDER TUMORS: LONG-TERM ONCOLOGICAL OUTCOMES OF PATIENTS UNDER ACTIVE SURVEILLANCE Edoardo Beatrici, Roberto Contieri, Nicola Frego, Vittorio Fasulo, Pietro Diana, Marco Paciotti, Davide Maffei, Pier Paol Avolio, Alessandro Uleri, Cesare Saitta, Paola Arena, Giuseppe Chiarelli, Andrea Gobbo, Nicolò Maria Buffi, Massimo Lazzeri, Paolo Casale, Alberto Saita, Giorgio Guazzoni, Giovanni Lughezzani, and Rodolfo Hurle Edoardo BeatriciEdoardo Beatrici More articles by this author , Roberto ContieriRoberto Contieri More articles by this author , Nicola FregoNicola Frego More articles by this author , Vittorio FasuloVittorio Fasulo More articles by this author , Pietro DianaPietro Diana More articles by this author , Marco PaciottiMarco Paciotti More articles by this author , Davide MaffeiDavide Maffei More articles by this author , Pier Paol AvolioPier Paol Avolio More articles by this author , Alessandro UleriAlessandro Uleri More articles by this author , Cesare SaittaCesare Saitta More articles by this author , Paola ArenaPaola Arena More articles by this author , Giuseppe ChiarelliGiuseppe Chiarelli More articles by this author , Andrea GobboAndrea Gobbo More articles by this author , Nicolò Maria BuffiNicolò Maria Buffi More articles by this author , Massimo LazzeriMassimo Lazzeri More articles by this author , Paolo CasalePaolo Casale More articles by this author , Alberto SaitaAlberto Saita More articles by this author , Giorgio GuazzoniGiorgio Guazzoni More articles by this author , Giovanni LughezzaniGiovanni Lughezzani More articles by this author , and Rodolfo HurleRodolfo Hurle More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002633.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Active Surveillance (AS) has been proposed as a conservative approach in Low-grade Non-Muscle-invasive Bladder cancers (NMIBC), in order to avoid or postpone invasive surgical treatments. We present an update of Bladder Cancer Italian Active Surveillance (BIAS) project, to confirm the safety of AS in terms of oncological long-term outcomes. The primary objective of the study is to investigate the rate of failure at a long-term FU. The secondary objective is to report oncological outcomes of patients who failed. METHODS: This prospective observational study, currently on-going, started in January 2013, including patients with pathologically confirmed Ta/T1 low grade NMIBC who experienced recurrence during follow-up (FU) and voluntary accepted AS monitoring. Inclusion criteria were: history of Low-Grade NMIBC (G1-G2) pTa/pT1; number of tumors between 1 and 5; size of larger tumor < 1 cm; absence of hematuria; negative urine cytology (UC). Failure was defined as reaching 1 or more of the exclusion criteria after enrolment. AS monitoring consisted in UC and flexible in-office cystoscopy every 3 months for the first year and then every 6 months. RESULTS: BIAS protocol included 229 patients (271 AS events). Median (IQR) age at AS entrance was 72 years (65-79). Median time from last TURB to AS enrolment was 11 months (6-21). At last Trans-urethral Resection of Bladder (TURB) before AS, population presented multifocal lesions in 73 cases, in 190 cases lesions were ≤ 5mm. Median time on AS was 16 months (6-28). Overall, we recorded 160 failure due to increase of lesion’s number or dimension in 87 and 101 cases respectively, gross hematuria in 16, positive UC in 16, voluntary exit in 4. We also registered 5 cases of tumor regression during AS period. At failure TURB, in 19 cases there were an upstage to HG\CIS, in 1 case an upstage to T2, while 26 cases were negative. Actually, 86 patients are still on AS. We also evaluated the FU of patients who experienced AS failure and exit from protocol (median FU 38 months [24/52]): 102 of theme did not undergo any other TURB during FU. In those who underwent 1 or more TURB, most frequent histological finding was pTa in 52 patients, while we registered pT1 in only 8 cases and pT2 in 0 cases. Only 15 patients experienced an upstage to HG\CIS. CONCLUSIONS: This update confirms the safety in terms of oncological outcomes of AS in Low-grade NMIBC. Our findings are bolstered by data derived from the FU of patients who failed AS and exit our protocol. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e931 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Edoardo Beatrici More articles by this author Roberto Contieri More articles by this author Nicola Frego More articles by this author Vittorio Fasulo More articles by this author Pietro Diana More articles by this author Marco Paciotti More articles by this author Davide Maffei More articles by this author Pier Paol Avolio More articles by this author Alessandro Uleri More articles by this author Cesare Saitta More articles by this author Paola Arena More articles by this author Giuseppe Chiarelli More articles by this author Andrea Gobbo More articles by this author Nicolò Maria Buffi More articles by this author Massimo Lazzeri More articles by this author Paolo Casale More articles by this author Alberto Saita More articles by this author Giorgio Guazzoni More articles by this author Giovanni Lughezzani More articles by this author Rodolfo Hurle More articles by this author Expand All Advertisement PDF DownloadLoading ...