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Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events

2022; Nature Portfolio; Volume: 13; Issue: 1 Linguagem: Inglês

10.1038/s41467-022-29522-y

2041-1723

Rachael Pung, Josh A. Firth, Lewis G. Spurgin, Annie Chang, Jade Kong, Jazzy Wong, Ooi Jo Jin, Deepa Selvaraj, Dominique Z X Yong, Jocelyn H S Lang, Abilash Sivalingam, Simon R. Procter, Stefan Flasche, William Waites, Kiesha Prem, Carl A. B. Pearson, Hamish Gibbs, Katharine Sherratt, Christian Julián Villabona‐Arenas, Kerry LM Wong, Yang Liu, Paul Mee, Lloyd A. C. Chapman, Katherine E. Atkins, Matthew Quaife, James D. Munday, Sebastian Funk, Rosalind M. Eggo, Stéphane Hué, Nicholas G. Davies, David Hodgson, Kaja Abbas, Ciara V. McCarthy, Joel Hellewell, Sam Abbott, Nikos I Bosse, Oliver J. Brady, Rosanna C. Barnard, Mark Jit, Damien C. Tully, Graham F. Medley, Fiona Yueqian Sun, Christopher I Jarvis, Rachel Lowev, Kathleen O’Reilly, Sophie Meakin, Akira Endo, Frank Sandmann, W. John Edmunds, Mihály Koltai, Emilie Finch, Amy Gimma, Alicia Roselló, Billy J. Quilty, Yalda Jafari, Gwenan M. Knight, Samuel Clifford, Timothy Russell, Vernon J. Lee, Adam J. Kucharski,

Vaccine Coverage and Hesitancy

Abstract The emergence of highly transmissible SARS-CoV-2 variants has created a need to reassess the risk posed by increasing social contacts as countries resume pre-pandemic activities, particularly in the context of resuming large-scale events over multiple days. To examine how social contacts formed in different activity settings influences interventions required to control Delta variant outbreaks, we collected high-resolution data on contacts among passengers and crew on cruise ships and combined the data with network transmission models. We found passengers had a median of 20 (IQR 10–36) unique close contacts per day, and over 60% of their contact episodes were made in dining or sports areas where mask wearing is typically limited. In simulated outbreaks, we found that vaccination coverage and rapid antigen tests had a larger effect than mask mandates alone, indicating the importance of combined interventions against Delta to reduce event risk in the vaccine era.