The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters
2022; Elsevier BV; Volume: 198; Linguagem: Inglês
10.1016/j.antiviral.2022.105253
ISSN1872-9096
AutoresRana Abdelnabi, Caroline S. Foo, Xin Zhang, Viktor Lemmens, Piet Maes, Bram Slechten, Joren Raymenants, Emmanuel André, Birgit Weynand, Kai Dallmeier, Johan Neyts,
Tópico(s)SARS-CoV-2 detection and testing
ResumoThe emergence of SARS-CoV-2 variants of concern (VoCs) has exacerbated the COVID-19 pandemic. End of November 2021, a new SARS-CoV-2 variant namely the omicron (B.1.1.529) emerged. Since this omicron variant is heavily mutated in the spike protein, WHO classified this variant as the 5th variant of concern (VoC). We previously demonstrated that the ancestral strain and the other SARS-CoV-2 VoCs replicate efficiently in and cause a COVID19-like pathology in Syrian hamsters. We here wanted to explore the infectivity of the omicron variant in comparison to the ancestral D614G strain in the hamster model. Strikingly, in hamsters that had been infected with the omicron variant, a 3 log
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