Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms
2022; eLife Sciences Publications Ltd; Volume: 11; Linguagem: Inglês
10.7554/elife.63998
ISSN2050-084X
AutoresRebecca C. Schugar, Christy M. Gliniak, Lucas J. Osborn, William J. Massey, Naseer Sangwan, Anthony Horak, Rakhee Banerjee, Danny Orabi, Robert N. Helsley, Amanda L. Brown, Amy Burrows, Chelsea Finney, Kevin Fung, Frederick M. Allen, Daniel Ferguson, Anthony D. Gromovsky, Chase Neumann, Kendall Cook, Amy McMillan, Jennifer A. Buffa, James T. Anderson, Margarete Mehrabian, Maryam Goudarzi, Belinda Willard, Tytus D. Mak, Andrew Armstrong, Garth Swanson, Ali Keshavarzian, José Carlos Garcı́a-Garcı́a, Zeneng Wang, Aldons J. Lusis, Stanley L. Hazen, J. Mark Brown,
Tópico(s)Tryptophan and brain disorders
ResumoObesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here, we show that gut microbe-targeted inhibition of the trimethylamine N-oxide (TMAO) pathway protects mice against the metabolic disturbances associated with diet-induced obesity (DIO) or leptin deficiency (
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