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Outcomes of laboratory‐confirmed SARS‐CoV ‐2 infection in the Omicron‐driven fourth wave compared with previous waves in the Western Cape Province, South Africa

2022; Wiley; Volume: 27; Issue: 6 Linguagem: Inglês

10.1111/tmi.13752

1365-3156

Mary‐Ann Davies, Reshma Kassanjee, Petro Rousseau, Erna Morden, Leigh F. Johnson, Wesley Solomon, Marvin Hsiao, Hannah Hussey, Graeme Meintjes, Masudah Paleker, Theuns Jacobs, Peter Raubenheimer, Alexa Heekes, Pierre Dane, Jamy‐Lee Bam, Mariette Smith, Wolfgang Preiser, David Pienaar, Marc Mendelson, Jonathan Naudé, Neshaad Schrueder, Ayanda Trevor Mnguni, Sue Le Roux, Kathleen Murie, Hans Prozesky, Hassan Mahomed, Liezel Rossouw, Sean Wasserman, Deborah Maughan, Linda Boloko, Barry Smith, Jantjie Taljaard, Greg Symons, Ntobeko Ntusi, Arifa Parker, Nicole Wolter, Waasila Jassat, Cheryl Cohen, Richard Lessells, Robert J. Wilkinson, Juanita Arendse, Saadiq Kariem, Melvin Moodley, Milani Wolmarans, Keith Cloete, Andrew Boulle,

Viral Infections and Outbreaks Research

The objective was to compare COVID-19 outcomes in the Omicron-driven fourth wave with prior waves in the Western Cape, assess the contribution of undiagnosed prior infection to differences in outcomes in a context of high seroprevalence due to prior infection and determine whether protection against severe disease conferred by prior infection and/or vaccination was maintained.