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Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients – study rationale and protocol of the CORONIS study: A multicentre prospective cohort study

2022; SAGE Publishing; Volume: 7; Issue: 2 Linguagem: Inglês

10.1177/23969873221092538

2396-9881

Theresa J. van Lith, Wouter M. Sluis, Naomi T. Wijers, Frederick J. A. Meijer, Karin Kamphuis-van Ulzen, Jeroen de Bresser, Jan Willem Dankbaar, Frederik MA van den Heuvel, M. Louisa Antoni, Catharina M. Mulders‐Manders, Quirijn de Mast, Frank L. van de Veerdonk, Frederikus A. Klok, Anil M. Tuladhar, Suzanne C. Cannegieter, Marieke J.H. Wermer, H. Bart van der Worp, Menno V. Huisman, Frank‐Erik de Leeuw,

COVID-19 Clinical Research Studies

COVID-19 is often complicated by thrombo-embolic events including ischemic stroke. The underlying mechanisms of COVID-19-associated ischemic stroke, the incidence and risk factors of silent cerebral ischemia, and the long-term functional outcome in these patients are currently unknown.CORONavirus and Ischemic Stroke (CORONIS) is a multicentre prospective cohort study investigating the prevalence, risk factors and long-term incidence of (silent) cerebral ischemia, and the long-term functional outcome among patients with COVID-19. We aim to include 200 adult patients hospitalized with COVID-19 without symptomatic ischemic stroke to investigate the prevalence of silent cerebral ischemia compared with 60 (matched) controls with MRI. In addition, we will identify potential risk factors and/or causes of cerebral ischemia in COVID-19 patients with (n = 70) or without symptomatic stroke (n = 200) by means of blood sampling, cardiac workup and brain MRI. We will measure functional outcome and cognitive function after 3 and 12 months with standardized questionnaires in all patients with COVID-19. Finally, the long-term incidence of (new) silent cerebral ischemia in patients with COVID-19 will be assessed with follow up MRI (n = 120).The CORONIS study is designed to add further insight into the prevalence, long-term incidence and risk factors of cerebral ischemia, and the long-term functional outcome in hospitalized adult patients with COVID-19.