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Altered Brain Network Functional Connectivity One Month Following Pediatric Concussion

2022; RELX Group (Netherlands); Linguagem: Inglês

10.2139/ssrn.4055849

1556-5068

Katherine Healey, Zhuo Fang, Andra Smith, Roger Zemek, Andrée‐Anne Ledoux,

Heart Rate Variability and Autonomic Control

Concussion is a mild traumatic brain injury (mTBI) with increasing prevalence among children and adolescents. Functional connectivity (FC) within and between the default mode network (DMN), central executive network (CEN) and salience network (SN) has been shown to be altered post-concussion. Few studies have investigated connectivity within and between these 3 networks following a pediatric concussion. The present study explored whether within and between-network FC differs between a pediatric concussion and orthopedic injury (OI) group aged 10-18. Participants underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan at 4 weeks post-injury. One-way ANCOVA analyses were conducted between groups with the seed-based FC of the 3 networks. A total of 55 concussion and 27 OI participants were included in the analyses. Increased within-network FC of the CEN and SN, increased between-network FC of the DMN-SN and CEN-SN, and decreased between-network FC of the DMN-CEN was found in the concussion group when compared to the OI group. This study identified differential connectivity patterns following a pediatric concussion as compared to an OI 4-weeks post-injury. These differences indicate potential adaptive brain mechanisms that may provide insight into recovery trajectories and appropriate timing of treatment within the first month following a concussion.Funding Information: This work was supported by the IMPACT OSSU Award; the PSI Foundation; and graduate student funding by the Canadian Institutes of Health Research (CIHR). Declaration of Interests: RZ is supported with a Clinical Research Chair in Pediatric Concussion from University of Ottawa, and he is the co-founder, Scientific Director and a minority shareholder in 360 Concussion Care, an interdisciplinary concussion clinic. No other interests are declared. Ethics Approval Statement: The study was approved by the Research Ethics Board at CHEO and was carried out in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki). Participants and parent/guardian provided written informed consent and/or assent as appropriate.