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Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations

2022; Lippincott Williams & Wilkins; Volume: 79; Issue: 6 Linguagem: Inglês

10.1161/hypertensionaha.122.19078

1524-4563

Alexandra Heath‐Freudenthal, Lilian Toledo-Jaldin, Inge von Alvensleben, Litzi Lazo-Vega, Rodrigo Mizutani, Margaret Stalker, Hussna Yasini, Fanny Mendizábal, Jesus Dorado Madera, William Mundo, Melany Castro-Monrroy, Julie A. Houck, Any Moreno-Aramayo, Valquiria Miranda-Garrido, Emily Su, Dino A. Giussani, Steven H. Abman, Lorna G. Moore, Colleen G. Julian,

Neonatal Respiratory Health Research

Preeclampsia and fetal growth restriction increase cardiopulmonary disease risk for affected offspring and occur more frequently at high-altitude (≥2500 m). Retrospective studies indicate that birth to a preeclampsia woman at high altitude increases the risk of pulmonary hypertension (PH) in later life. This prospective study asked whether preeclampsia with or without fetal growth restriction exaggerated fetal hypoxia and impaired angiogenesis in the fetal lung, leading to neonatal cardiopulmonary circulation abnormalities and neonatal or infantile PH.