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Utility of a cloud-based lesion data collection software to record, monitor, and analyze an ablation strategy

2022; Elsevier BV; Volume: 3; Issue: 3 Linguagem: Inglês

10.1016/j.hroo.2022.03.006

2666-5018

Omar Kreidieh, John Whitaker, Clinton J. Thurber, Mati Amit, Liat Tsoref, Stanislav Goldberg, Don Yungher, Nathaniel Steiger, Thomas M. Tadros, Sunil Kapur, Bruce A. Koplan, Usha B. Tedrow, William H. Sauer, Paul C. Zei,

Venous Thromboembolism Diagnosis and Management

Key Findings▪A cloud-based AI/machine learning system can be used to analyze detailed ablation data obtained during catheter ablation.▪This strategy allowed demonstration of predictors of need for "touch up" ablation during pulmonary vein isolation.▪This approach may be applied to a broad range of ablation procedures and parameter analysis in the future. Catheter radiofrequency (RF) ablation–based pulmonary vein isolation is the predominant approach to ablation of atrial fibrillation (AF). Attempts to improve success rates have included real-time monitoring of factors related to lesion formation, such as contact force (CF), power, impedance changes, lesion duration, and calculated indices such as ablation index (AI) (SURPOINT, Biosense Webster, Diamond Bar, CA). Data created from each lesion typically are lost because of logistical challenges related to storage, retrieval, and analysis. Cloud storage and analysis may alleviate some of these difficulties and enhance the use of these data for research, clinical quality improvement, and clinical reporting. We sought to describe our experience with this technology. We used CARTONET, a new cloud storage and analysis software (Biosense Webster), to evaluate our adherence to an ablation protocol (demonstrating clinical use) and to examine the predictors of additional ablation in a segment (research potential) (Figure 1). This study was approved by the institutional review board (IRB) of Brigham and Women's Hospital. Single-operator first-time AF RF ablations performed between June 3, 2018, and December 9, 2020, were included. Procedural data were uploaded to the CARTONET cloud analysis software. AF ablation was performed with trainee participation using a standardized zero fluoroscopy workflow.1Zei P. Quadros K. Clopton P. et al.Safety and efficacy of minimal- versus zero-fluoroscopy radiofrequency catheter ablation for atrial fibrillation: a multicenter, prospective study.J Innov Card Rhythm Manag. 2020; 11: 4281-4291Crossref PubMed Google Scholar CF between 5 and 40 g was targeted. Anteriorly, power of 40–50 W and AI between 450 and 500 were targeted. Posteriorly, power of 40–50 W and AI of 350–400 were targeted. During ablation, VISITAGs were generated when RF applications exhibited stability for up to 3 mm for at least 3 seconds with respiratory phase adjustment (Figure 1). Location at end of expiration was used for anatomic coordinates. Information from generated VISITAGs for all cases was uploaded to CARTONET for automated analysis. Procedural data were securely transferred from CARTO 3 workstations (Biosense Webster) to the Siemens teamplay gateway (Siemens, Malvern, PA). Files were scrubbed of patient identifiers, and the anonymized data were transmitted to the Microsoft Azure cloud (Microsoft Corp., Redmond, WA), where storage and machine learning–based lesion location assignment is performed. Lesion parameters included maximum power, average CF, stability, RF duration, force–time integral, AI, baseline impedance, and impedance drop. Stability was defined as the 90th percentile of catheter deviation from a mean position during RF delivery. A Web site was used to review a timeline of ablation lesions. The machine learning–based lesion locations were adjusted as needed. Ablations performed after an initial full encirclement of the veins were deemed additional ablation sites labeled as touchup lesions retrospectively (Figure 2). Data were downloaded in bulk for review. Statistical analysis was performed using Python and SPSS Version 21 (IBM Corp., Armonk, NY). Proportions across groups were compared using χ2 analysis. We classified lesions by adherence to the ablation strategy targets outlined earlier. For AI, we allowed for a 25-unit flexibility so that anteriorly lesions were within target between 425–525 of AI and posteriorly the values were 325–425. Intermediate locations were allowed to fall within the anterior and posterior defined ranges. A total of 62 patients and 6391 pulmonary vein isolation lesions were analyzed. CF targets were met by 97.7% of ablation lesions, AI targets by 78.3%, power targets in 87.7%, impedance drop ≥10 Ω in 26.4%, and impedance drop ≥7 Ω in 52.0%. Regional differences were common (Table 1).Table 1Ablation target compliance by regionNo.CF target achieved (%)P value compared to all other segmentsAI target achieved (%)P value compared to all other segmentsPower target achieved (%)P value compared to all other segmentsImpedance drop target 10 Ω achieved (%)P value compared to all other segmentsImpedance drop target 7 Ω achieved (%)P value compared to all other segmentsLeft PVI lesions Left ridge73794.0<.0176.7.2684.4.0128.2.2455.0.10 Left anterior52096.0.0164.0<.0170.6<.0127.1.7258.7<.01 Left inferior28298.9.2384.0.0297.2<.0125.5.8049.6.44 Left posterior78399.2<.0168.1<.0186.1.1725.7.6752.7.70 Left roof57796.9.2193.4<.0197.6<.0133.3<.0157.0.01 Left carina5096.0.7384.0.42100<.0120.0.4048.0.67 Total294996.8<.0176.1<.0186.2.0128.0.0154.9<.01Right PVI lesions Right anterior115799.0<.0177.3.3581.7<.0137.9<.0165.1<.01 Right inferior31098.1.8290.0<.0197.1<.0117.1<.0144.2<.01 Right posterior124198.8.0173.7<.0188.4.4015.5<.0135.1<.01 Right roof61798.5.1992.2<.0195.9<.0123.5.1052.2.97 Right carina11791.5<.0185.4.08100<.0128.2.6652.1.95 Total344298.7<.0180.0<.0188.3.0125.0.0149.6<.01Bold values are statistically significant.AI = ablation index; CF = contact force; PVI = pulmonary vein isolation. Open table in a new tab Bold values are statistically significant. AI = ablation index; CF = contact force; PVI = pulmonary vein isolation. Parameters related to the need for additional ablation included segment length, minimum CF, minimum duration, minimum force–time integral, minimum AI, minimum power, and worse stability. Conversely, mean values were similar between segments that required additional ablation and those that did not (Table 2).Table 2Ablation parameters in RFPI and those with additional ablationCF (g)Duration (s)FTI (g s)Impedance drop (Ω)AIMeanMinMeanMinMeanMinMeanMinMeanMinTouchup segment13.8 ± 3.56.2 ± 2.412.4 ± 3.27.0 ± 1.7161 ± 4764 ± 318.2 ± 2.40.8 ± 4.5412 ± 47310 ± 47RFPI14.1 ± 4.18.0 ± 3.611.9 ± 3.47.7 ± 2.2157 ± 4786 ± 428.1 ± 2.72.7 ± 3.3411 ± 50343 ± 43P value.37<.01.09<.01.33<.01.68<.010.85<.01Power (W)Stability (mm)MeanMinMeanMaxTouchup segment44.9 ± 4.641.1 ± 4.52.5 ± 0.65.4 ± 1.2RFPI45.4 ± 4.642.5 ± 4.82.4 ± 0.74.4 ± 1.4P value.30<.01.20<.01Bold values are statistically significant.FTI = force–time integral; RFPI = regions of first-pass isolation; other abbreviations as in Table 1. Open table in a new tab Bold values are statistically significant. FTI = force–time integral; RFPI = regions of first-pass isolation; other abbreviations as in Table 1. We present the first description of using a cloud-based storage and analysis system in cardiac electrophysiology with the following key findings: (1) Lesion-specific data can be stored and downloaded in bulk for facile clinical and research assessments. (2) Stored data are clinically relevant and were related to the need for additional ablation. The adoption of cloud storage and computing in medicine has been concentrated in the genomic and metabolomic fields, whereas applications related to health information exchange have lagged.2Griebel L. Prokosch H.-U. Köpcke F. et al.A scoping review of cloud computing in healthcare.BMC Med Inform Decis Mak. 2015; 15: 17Crossref PubMed Scopus (132) Google Scholar Ablation procedures offer an ideal application for such systems because of the amount of complex data generated. An ideal storage solution is secure, efficient, and easy to use, and stores clinically relevant information. In our report, we demonstrated a simple example of how to use one such tool to compile and review ablation data, which can be used for clinical assessments, quality improvement, or research. We successfully assessed adherence to our target strategy and identified predictors of touchup ablation in a segment. Ideally, indication of first-pass isolation would be stored prospectively in future iterations. Alternative use cases may rely on impedance drop stored for each lesion as a surrogate of lesion formation. Ongoing challenges to advancement of this technology include information security, system interoperability, and legal constraints. Despite current limitations, cloud-based analysis and storage has the potential to impact clinical care significantly by enabling physicians to assess and review their performance more easily. Adjustments to the ablation strategy or the adoption of new technologies can be systematically reviewed to detect signals of altered lesion parameters or impedance drops. Incorporation of these tools into trials and registries can alleviate logistical difficulties and allow for comprehensive lesion-based analysis. Lastly, the compilation of large amounts of lesion-specific procedural data will allow for greater power to detect subtle effects that otherwise would be difficult to study. Future studies should validate the accuracy of machine learning–based lesion location assignment and the clinical impact from using such systems. Additional ablation sites were identified when ablations followed encirclement and occasionally may represent reinforcement of a wide area circumferential ablation despite first-pass isolation. Experience of other operators/centers or newer software versions may differ. We describe a novel cloud-based storage system that utilizes machine learning to analyze ablation data obtained during catheter ablation for atrial fibrillation. Using this system, we demonstrate key ablation-related parameters that predict the need for additional ablation beyond initial first pass encirclement to achieve pulmonary vein isolation. There is significant potential for this system as a tool to analyze mapping and ablation procedure data and as a result improve procedural outcomes.