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SARS-CoV-2 vaccination diversifies the CD4+ spike-reactive T cell repertoire in patients with prior SARS-CoV-2 infection

2022; Elsevier BV; Volume: 80; Linguagem: Inglês

10.1016/j.ebiom.2022.104048

2352-3964

Arbor G. Dykema, Boyang Zhang, Bezawit A. Woldemeskel, Caroline C. Garliss, Rufiaat Rashid, Timothy Westlake, Li Zhang, Jiajia Zhang, Laurene S. Cheung, Justina X. Caushi, Drew M. Pardoll, Andrea L. Cox, Hongkai Ji, Kellie N. Smith, Joel N. Blankson,

vaccines and immunoinformatics approaches

COVID-19 mRNA vaccines elicit strong T and B cell responses to the SARS-CoV-2 spike glycoprotein in both SARS-CoV-2 naïve and experienced patients. However, it is unknown whether the post-vaccine CD4+ T cell responses seen in patients with a history of COVID-19 are due to restimulation of T cell clonotypes that were first activated during natural infection or if they are the result of new clones activated by the vaccine.