Portal de Periódicos da CAPES

Heterogeneity in the association between prediabetes categories and reduction on glomerular filtration rate in a 5-year follow-up

2022; Nature Portfolio; Volume: 12; Issue: 1 Linguagem: Inglês

10.1038/s41598-022-11392-5

2045-2322

Marjan Manouchehri, Lucía Cea Soriano, Josep Franch‐Nadal, Antonio Ruíz, Albert Goday, Rosa Villanueva, Javier Díez‐Espino, Manel Mata‐Cases, Carolina Giráldez‐García, Enrique Regidor, Jesús Torrecilla, Lourdes Carrillo, José Mancera, Teresa Mur, Rosario Mérida Serrano, Francisco Javier García Soidán, Gabriel Cuatrecasas, Dimas Igual, Ana Hernández Moreno, J. Manuel Millaruelo, Francisco Carramiñana, Manuel Antonio Ruiz, Francisco Carlos Pérez, Yon Iriarte, Ángela Lorenzo, María González, Beatriz Álvarez, Lourdes Barutell, Ma Soledad Mayayo, Mercedes del Castillo, Emma Navarro, Fernando Malo, Ainoha Cambra, Rosa Magallón-Botaya, Riánsares López, Mario Gutiérrez, Luisa Gutiérrez Gutiérrez, Carmen Boente, Javier Mediavilla, Luis Prieto, Luis Mendo, Ma José Mansilla, Francisco Javier Medrano Ortega, Antonia Borras, L. Gabriel Sánchez, Juan Carlos Obaya, Margarita Alonso, Francisco García, Ángela Trinidad Gutiérrez, Ana Ma Hernández, Dulce Suárez, Juan Carlos Álvarez, Isabel Sáenz, F. Javier Martínez, Ana Casorrán, Jazmín Ripoll, Alejandro Salanova, Ma Teresa Marín, Félix Gutiérrez, Jaime Innenaraty, Ma del Mar Álvarez, Sara Artola, Ma Jesús Bedoya, Santiago Póveda, Fernando Álvarez Guisasola, Ma Jesús Brito, Rosario Iglesias, Francisca Paniagua, Pedro Nogales, Ángel Gómez, Jóse Félix Rubio, Ma Carmen Durán-Ruiz, Julio Sagredo, Ma Teresa Gijón, Ma Angeles Rollán, Pedro P. Pérez, Javier Gamarra, F Carbonell, Luis García-Giralda, Joaquín Antón, Manuel de la Flor, Rosario Martínez, José Luis Pardo, Raquel Plana, Ramón Macía, Mercè Villaró, Carmen Babace, Concepción Blanco, Ángeles Jurado, José Luis Fernández Martín, Jorge Navarro, Gloria Sanz, Rafael Colás, Blanca Cordero, Cristina De Castro, Mercedes Ibáñez, Alicia Monzón, Núria Porta, María del Carmen Gómez, Rafael Llanes, Juan José Ramos Rodríguez, Esteban Granero, Manuel Sánchez, Juan Martínez, Patxi Ezkurra, Luis Ávila, Carlos de la Sen, Antonio Rodríguez‐Poncelas, Pilar Buil, Paula Gabriel, Pilar Roura, Eduard Tarragó, Xavier Mundet, Remei Bosch, J. Carles González, Ma Isabel Bobé, Irene Ruíz, Flora López, Ana Martínez Martínez, M Birulés, Oriol Armengol, Rosa De MarMiguel, Laura Romera, B. Benito, Neus Piulats, Beatriz Bilbeny, Joan Vila, Xavier Cos, Ramón M. Pujol, Mateu Seguí, Carmen Losada, A. De MaríaSantiago, Pedro Muñoz,

Diabetes Treatment and Management

Abstract Prediabetes and not just diabetes can cause kidney damage. This study assess the association of prediabetes with development of impaired renal function (IRF). We used data from PREDAPS prospective study a cohort of 1072 subjects with prediabetes and another cohort of 772 subjects without prediabetes were follow-up from 2012 to 2017. Prediabetes was defined according to American Association of Diabetes criteria. IRF was defined as having a glomerular filtration rate < 60 mL/min/1.73 m 2 . Incidence rates of IRF in both cohorts and in different categories of prediabetes, based on impaired glycosylated hemoglobin (HbA1c) and/or fasting plasma glucose (FPG), were calculated. Hazard ratios (HR) for the association of the prediabetes with IRF, adjusting for potential confounders, were estimated by Cox regression models. Incidence rates of IRF per 100 person-years were 1.72 (95% confidence interval [CI]: 1.34–2.21) and 1.79 (95%CI: 1.45–2.20) for those without and with prediabetes, respectively .The HR of IRF in subjects with prediabetes with respect to subjects without prediabetes was 0.76 (95% CI: 0. 54–1.07). Corresponding HRs for type of prediabetes was 0.68 (95%CI: 0.40–1.15) for those with both altered parameters, 0.68 (95%CI: 00.40–1.15) for those with only impaired HbA1c and 1.12 (95%CI: 0.68–1.85) for those with only impaired FPG. The present study reflects an overall trend towards a slightly decreased risk of IRF onset associated to prediabetes except for individuals with only isolated impaired FPG. Further studies are warranted to fully assess the renal progression of each group.