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Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021

2022; Nature Portfolio; Volume: 13; Issue: 1 Linguagem: Inglês

10.1038/s41467-022-30219-5

2041-1723

Collins M. Morang’a, Joyce M. Ngoi, Jones Gyamfi, Dominic S. Y. Amuzu, Benjamín Demah Nuertey, Philip M. Soglo, Vincent Appiah, Ivy Asantewaa Asante, Paul Owusu-Oduro, Samuel Armoo, Dennis Adu‐Gyasi, Nicholas Amoako, Joseph Oliver-Commey, Michael Owusu, Augustina Angelina Sylverken, Edward D. Fenteng, Violette V. M’cormack, Frederick Tei-Maya, Evelyn Quansah, Reuben Ayivor-Djanie, Enock K. Amoako, Isaac T. Ogbe, Bright K. Yemi, Israel Osei-Wusu, Deborah N. A. Mettle, Samirah Saiid, Kesego Tapela, Francis Dzabeng, Vanessa Magnussen, Jerry Quaye, Precious C. Opurum, Rosina Carr, Patrick Tetteh Ababio, Abdul-Karim Abass, Samuel Kaba Akoriyea, Emmanuella Amoako, Frederick Kumi-Ansah, Oliver D. Boakye, Dam K. Mibut, Theophilus Odoom, Lawrence Ofori-Boadu, Emmanuel Allegye‐Cudjoe, Sylvester Dassah, Victor Asoala, Kwaku Poku Asante, Richard Odame Phillips, Mike Y. Osei‐Atweneboana, John O. Gyapong, Patrick Kuma‐Aboagye, William Ampofo, Kwabena Obeng Duedu, Nicaise Tuikue Ndam, Yaw Bediako, Peter K. Quashie, Lucas Amenga–Etego, Gordon A. Awandare,

Plant Virus Research Studies

Abstract The COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, the SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 SARS-CoV-2 genomes from patient isolates (121 from arriving travellers and 1002 from communities) to track the molecular evolution and spatio-temporal dynamics of the SARS-CoV-2 variants in Ghana. The data show that initial local transmission was dominated by B.1.1 lineage, but the second wave was overwhelmingly driven by the Alpha variant. Subsequently, an unheralded variant under monitoring, B.1.1.318, dominated transmission from April to June 2021 before being displaced by Delta variants, which were introduced into community transmission in May 2021. Mutational analysis indicated that variants that took hold in Ghana harboured transmission enhancing and immune escape spike substitutions. The observed rapid viral evolution demonstrates the potential for emergence of novel variants with greater mutational fitness as observed in other parts of the world.